ArticleJournal of diabetes investigation2019
Metabolic syndrome increases cardiovascular risk in a population with prediabetes: A prospective study in a cohort of Chinese adults.
Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Visceral Obesity and Lipid Profiles in Chinese Adults with Normal and High Body Mass Index.Diagnostics (Basel, Switzerland) · 2022Article
- Association of Metabolic Syndrome With Long-Term Cardiovascular Risks and All-Cause Mortality in Elderly Patients With Obstructive Sleep Apnea.Frontiers in cardiovascular medicine · 2021Article
- Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study.Cardiovascular diabetology · 2020Article
- Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study.Journal of diabetes investigation · 2020Article
- Higher triglyceride to high-density lipoprotein cholesterol ratio increases cardiovascular risk: 10-year prospective study in a cohort of Chinese adults.Journal of diabetes investigation · 2020Article
- Metabolic Syndrome Among Working Adults in Eastern Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Metabolic syndrome increases cardiovascular risk in a population with prediabetes: A prospective study in a cohort of Chinese adults.Journal of diabetes investigation · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
AIMS/
introductionThe prevalence of prediabetes has become a global epidemic, and prediabetes is often accompanied with metabolic syndrome (MS). However, the association between MS and cardiovascular (CV) risk among individuals with prediabetes in China remains unknown. The present study aimed to identify the relationship of MS with CV risk in Chinese adults with prediabetes. MATERIALS AND
methodsAltogether, 19,464 participants with prediabetes were enrolled at baseline and were followed up prospectively. Prediabetes is defined as a fasting plasma glucose level between 5.6 and 6.9 mmol/L, and with neither a history of diabetes nor current use of hypoglycemic drugs. Participants were classified on the basis of the presence of MS, according to the definition of the International Diabetes Federation. Main outcomes include major CV events. Incidence rates were expressed in cumulative incidence and person-years incidence. Cox proportional hazards analysis was used to estimate the risk of major CV events.
resultsAt baseline, the mean age was 51.9 ± 11.4 years, and 85.6% (n = 16,663) were men. During a median follow-up period of 10.0 years, a total of 1,169 major CV events occurred, including 921 strokes and 273 cases of myocardial infarction. The cumulative incidences were 9.0% (8.1-10.0%), 6.8% (6.0-7.6%) and 2.5% (2.0-3.0%) for total CV events, strokes and myocardial infarction. Regardless of the risk of total CV events, or the risk of stroke or myocardial infarction, the number of prediabetes individuals with MS was higher than those without, and the hazard ratio was 1.50 (95% confidence interval 1.31-1.73), 1.42 (95% confidence interval 1.21-1.67), 1.78 (95% confidence interval 1.34-2.36), respectively.
conclusionsAmong the Chinese population with prediabetes, the risk for major CV events was significantly higher in those with MS than those without.
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