Observational studyJournal of veterinary internal medicine2018
Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers.
Observational study in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Dogs with severe tracheal flattening exhibit lower degrees of left lateralization of the cervical esophagus.The Journal of veterinary medical science · 2024Article
- Extraesophageal reflux and reflux aspiration in dogs with respiratory diseases and in healthy dogs.Journal of veterinary internal medicine · 2023Article
- Polycythemia in dogs with chronic hypoxic pulmonary disease.Journal of veterinary internal medicine · 2022Article
- Quantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis.BMC veterinary research · 2022Article
- A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans.Frontiers in veterinary science · 2022Review
- Matrix metalloproteinase-2, -7, and -9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases.Journal of veterinary internal medicine · 2021Article
- Proteomic Characterization of Canine Gastric Fluid by Liquid Chromatography-Mass Spectrometry for Development of Protein Biomarkers in Regurgitation, Vomiting, and Cough.Frontiers in veterinary science · 2021Article
- Professional dental cleaning in dogs: clinical routines among Swedish veterinarians and veterinary nurses.Acta veterinaria Scandinavica · 2020Article
- Detection of silent reflux events by nuclear scintigraphy in healthy dogs.Journal of veterinary internal medicine · 2020Article
- Assessment of the lung microbiota in dogs: influence of the type of breed, living conditions and canine idiopathic pulmonary fibrosis.BMC microbiology · 2020Article
- Respiratory dysbiosis and population-wide temporal dynamics in canine chronic bronchitis and non-inflammatory respiratory disease.PloS one · 2020Article
- Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006-2016).Journal of veterinary internal medicine · 2019Article
- Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers.Journal of veterinary internal medicine · 2018Observational
- A One Health review of aerodigestive disease in dogs.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs.
objectiveTo detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases. ANIMALS: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles
methodsProspective cross-sectional observational study with convenience sampling of dogs. Bile acids were measured by mass spectrometry in BALF samples. Total bile acid (TBA) concentration was calculated as a sum of 17 different bile acids.
resultsConcentrations of TBA were above the limit of quantification in 78% of CIPF, 45% of BP, 62% of CB, 44% of EBP, 68% of LD, and 13% of IWH dogs. In healthy dogs, bile acids were detected less commonly in Beagles (0/6) than in healthy WHWTs (10/13). Concentrations of TBA were significantly higher in CIPF (median 0.013 μM, range not quantifiable [n.q.]-0.14 μM, P < .001), healthy WHWTs (0.0052 μM, n.q.-1.2 μM, P = .003), LD (0.010 μM, n.q.-2.3 μM, P = .015), and CB (0.0078 μM, n.q.-0.073 μM, P = .018) groups compared to Beagles (0 μM, n.q.). CONCLUSION AND CLINICAL IMPORTANCE: These results suggest that MA occurs in various respiratory diseases of dogs and also in healthy WHWTs.
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