Evidence map›Paper›PMID 30311910›Full record

ArticleeLife2018

Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A.

Andy Km Lam, Raimund Dutzler

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Review
  3. Allosteric coupling between PIPProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  8. Predicting Mutational Effects on CaJournal of the American Chemical Society · 2024
    Article
  9. Review
  10. Article
  11. KCNE1 does not shift TMEM16A from a CaPflugers Archiv : European journal of physiology · 2023
    Article
  12. Article
  13. Article
  14. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  15. Review
  16. An outer-pore gate modulates the pharmacology of the TMEM16A channel.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Divalent Cation Modulation of Ion Permeation in TMEM16 Proteins.International journal of molecular sciences · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andy Km LamDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-2983-3044
Raimund DutzlerDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2193-6129
University of Zurich · CH

Funding

H2020 European Research Council ERC no 339116 AnoBest
6 · The paper itself

Abstract

TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca

Indexed as

Protein ConformationAnimalsAnionsAnoctamin-1Binding SitesCalciumCalcium Channel AgonistsHEK293 CellsHumansIon Channel GatingMiceModels, MolecularMutant ProteinsStatic ElectricityAnionsAnoctamin-1CalciumCalcium Channel AgonistsMutant Proteinsanoctaminselectrophysiologyelectrostaticsion conductionligand-gated ion channelmolecular biophysicsmousestructural biology

Identifiers

PMID30311910
PMCPMC6195346
OpenAlexW2896540593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.