Evidence map›Paper›PMID 30311908›Full record

ArticleeLife2018

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis.

Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  12. Frontiers in endocrinology · 2022
    Article
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  19. Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism.Current opinion in endocrine and metabolic research · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 3 countries.

Sophie CroizierThe Saban Research Institute, Developmental Neuroscience Program, Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, United States.ORCID 0000-0002-0076-1008
Soyoung ParkThe Saban Research Institute, Developmental Neuroscience Program, Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, United States.
Julien MaillardThe Saban Research Institute, Developmental Neuroscience Program, Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, United States.
Sebastien G BouretThe Saban Research Institute, Developmental Neuroscience Program, Diabetes and Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, United States.ORCID 0000-0002-4174-9769
University of Southern California · US

Funding

Leptin and the Nutritional Programming of Obesity and DiabetesR01DK084142 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEVITT, PAT · 2010 to 2022
$4.3M
Hypothalamic miRNAs in the Pathogenesis of ObesityR01DK102780 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BOURET, SEBASTIEN G · 2015 to 2017
$1.2M
Molecular Mechanisms Underlying the Development of the Melanocortin SystemR01DK118401 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BOURET, SEBASTIEN G · 2018 to 2019
$848k
NIDDK NIH HHS DK102780NIDDK NIH HHS DK118401NIDDK NIH HHS DK84142NIDDK NIH HHS R01 DK084142NIDDK NIH HHS R01 DK102780NIDDK NIH HHS R01 DK118401
6 · The paper itself

Abstract

Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype. However, the mechanisms underlying the differentiation of

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalAnimalsGlucoseHomeostasisMiceMicroRNAsNeuronsNeuropeptide YPro-OpiomelanocortinGlucoseMicroRNAsMIRN103 microRNA, mouseMIRN107 microRNA, mouseNeuropeptide YPro-Opiomelanocortindevelopmentglucose homeostasishypothalamusmiRNAmouseneuroscienceobesityProopiomelanocortin

Identifiers

PMID30311908
PMCPMC6203430
OpenAlexW2885583141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.