ArticleeLife2018
Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- GluN2A Enables Noradrenergic Control of Prefrontal Oscillations and Cognitive Flexibility.eNeuro · 2026Article
- Neural Circuit with Top-Down Inhibitory Feedback Outperforms Optimal Bayesian Integration in Multisensory Integration.Neuroscience bulletin · 2026Article
- Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits.bioRxiv : the preprint server for biology · 2025Article
- Cholecystokinin-expressing interneurons mediated inhibitory transmission and plasticity in basolateral amygdala modulate stress-induced anxiety-like behaviors in mice.Neurobiology of stress · 2024Article
- Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience.PLoS biology · 2023Article
- Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism.Frontiers in cellular neuroscience · 2023Article
- Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain.Neuron · 2022Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
- In vivo extracellular recordings of thalamic and cortical visual responses reveal V1 connectivity rules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion.Frontiers in cellular neuroscience · 2022Article
- Nonlinear transient amplification in recurrent neural networks with short-term plasticity.eLife · 2021Article
- Distinct recruitment of feedforward and recurrent pathways across higher-order areas of mouse visual cortex.Current biology : CB · 2021Article
- The organization and development of cortical interneuron presynaptic circuits are area specific.Cell reports · 2021Article
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- The critical period: neurochemical and synaptic mechanisms shared by the visual cortex and the brain stem respiratory system.Proceedings. Biological sciences · 2021Review
- Article
- Stability of neocortical synapses across sleep and wake states during the critical period in rats.eLife · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Brief (2-3d) monocular deprivation (MD) during the critical period induces a profound loss of responsiveness within binocular (V1b) and monocular (V1m) regions of rodent primary visual cortex. This has largely been ascribed to long-term depression (LTD) at thalamocortical synapses, while a contribution from intracortical inhibition has been controversial. Here we used optogenetics to isolate and measure feedforward thalamocortical and feedback intracortical excitation-inhibition (E-I) ratios following brief MD. Despite depression at thalamocortical synapses, thalamocortical E-I ratio was unaffected in V1b and shifted toward excitation in V1m, indicating that thalamocortical excitation was not effectively reduced. In contrast, feedback intracortical E-I ratio was shifted toward inhibition in V1m, and a computational model demonstrated that these opposing shifts produced an overall suppression of layer 4 excitability. Thus, feedforward and feedback E-I ratios can be independently tuned by visual experience, and enhanced feedback inhibition is the primary driving force behind loss of visual responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.