ArticleeLife2018
The fate of hippocampal synapses depends on the sequence of plasticity-inducing events.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Functional synaptic connectivity shapes spine stability in the hippocampus.Nature communications · 2026Article
- Cerebrolysin Ameliorates Age-Induced Dendritic Spine Degeneration and Memory Decline in C57BL6 Mice.Neurochemical research · 2025Article
- Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses.iScience · 2025Article
- Competitive plasticity to reduce the energetic costs of learning.PLoS computational biology · 2024Article
- Amyloid-βiScience · 2023Article
- Review
- Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines.The EMBO journal · 2022Article
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly.The Journal of cell biology · 2022Article
- The Intriguing Contribution of Hippocampal Long-Term Depression to Spatial Learning and Long-Term Memory.Frontiers in behavioral neuroscience · 2022Review
- Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation.PLoS biology · 2021Article
- A spike-timing-dependent plasticity rule for dendritic spines.Nature communications · 2020Article
- Local cortical overexpression of human wild-type alpha-synuclein leads to increased dendritic spine density in mouse.Neuroscience letters · 2020Article
- Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience.Frontiers in molecular neuroscience · 2020Review
- How Dendrites Affect Online Recognition Memory.PLoS computational biology · 2019Article
- Single Synapse LTP: A Matter of Context?Frontiers in cellular neuroscience · 2019Review
- The Stability of Glutamatergic Synapses Is Independent of Activity Level, but Predicted by Synapse Size.Frontiers in cellular neuroscience · 2019Article
- Imaging and Analysis of Presynaptic Calcium Influx in Cultured Neurons Using synGCaMP6f.Frontiers in synaptic neuroscience · 2019Article
- Invasive and Non-invasive Stimulation of the Obese Human Brain.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Synapses change their strength in response to specific activity patterns. This functional plasticity is assumed to be the brain's primary mechanism for information storage. We used optogenetic stimulation of rat hippocampal slice cultures to induce long-term potentiation (LTP), long-term depression (LTD), or both forms of plasticity in sequence. Two-photon imaging of spine calcium signals allowed us to identify stimulated synapses and to follow their fate for the next 7 days. We found that plasticity-inducing protocols affected the synapse's chance for survival: LTP increased synaptic stability, LTD destabilized synapses, and the effect of the last stimulation protocol was dominant over earlier stimulations. Interestingly, most potentiated synapses were resistant to depression-inducing protocols delivered 24 hr later. Our findings suggest that activity-dependent changes in the transmission strength of individual synapses are transient, but have long-lasting consequences for synaptic lifetime.
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