Evidence map›Paper›PMID 30311689›Full record

ArticleMagnetic resonance in medicine2019

Whole-heart spiral simultaneous multi-slice first-pass myocardial perfusion imaging.

Yang Yang, Craig H Meyer, Frederick H Epstein, Christopher M Kramer, Michael Salerno

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
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  4. Simultaneous multi-slice cardiac real-time MRI at 0.55T.Magnetic resonance in medicine · 2025
    Article
  5. Article
  6. High-resolution quantification of stress perfusion defects by cardiac magnetic resonance.European heart journal. Imaging methods and practice · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cardiac MR: From Theory to Practice.Frontiers in cardiovascular medicine · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang YangDepartments of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia.
Craig H MeyerRadiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia.
Frederick H EpsteinRadiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia.
Christopher M KramerDepartments of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia.
Michael SalernoDepartments of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Virginia.

Funding

Training in Cardiovascular Imaging ResearchT32EB003841 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jonathan R Lindner · 2004 to 2026
$4.4M
High-Resolution Whole Heart Quantitative CMR Perfusion Imaging in Ischemic Heart DiseaseR01HL131919 · NHLBI · UNIVERSITY OF VIRGINIA · PI ENNIS, DANIEL B · 2017 to 2021
$3.5M
Quantitative Adenosine Stress CMR with Spiral Pulse SequencesK23HL112910 · NHLBI · UNIVERSITY OF VIRGINIA · PI SALERNO, MICHAEL · 2012 to 2016
$789k
NHLBI NIH HHS K23 HL112910NHLBI NIH HHS NIH K23 HL112910NHLBI NIH HHS NIH R01 HL131919NHLBI NIH HHS R01 HL131919NIBIB NIH HHS T32 EB003841Siemens
6 · The paper itself

Abstract

purposeTo develop and evaluate a simultaneous multislice (SMS) spiral perfusion pulse sequence with whole-heart coverage.

methodsAn orthogonal set of phase cycling angles following a Hadamard pattern was incorporated into a golden-angle (GA) variable density spiral perfusion sequence to perform SMS imaging at different multiband (MB) factors. Images were reconstructed using an SMS extension of L1-SPIRiT that we have termed SMS-L1-SPIRiT. The proposed sequence was evaluated in 40 subjects (10 each for MB factors of 1, 2, 3, and 4). Images were blindly graded by 2 cardiologists on a 5-point scale (5, excellent). To quantitatively evaluate the reconstruction performance against images acquired without SMS, the MB =1 data were used to retrospectively simulate data acquired at MB factors of 2 to 4.

resultsAnalysis of the SMS point-spread function for the desired slice showed that the proposed sampling strategy significantly canceled the main-lobe energy of the other slices and has low side-lobe energy resulting in an incoherent temporal aliasing pattern when rotated by the GA. Retrospective experiments demonstrated the SMS-L1-SPIRiT method removed aliasing from the interfering slices and showed excellent agreement with the ground-truth MB =1 images. Clinical evaluation demonstrated high-quality perfusion images with average image-quality scores of 4.3 ± 0.5 (MB =2), 4.2 ± 0.5 (MB =3), and 4.4 ± 0.4 (MB =4) with no significant quality difference in image quality between MB factors (P = 0.38).

conclusionSMS spiral perfusion at MB factors 2, 3, and 4 produces high-quality perfusion images with whole-heart coverage in a clinical setting with high sampling efficiency.

Indexed as

Myocardial Perfusion ImagingAdultAlgorithmsArrhythmias, CardiacAtrial FibrillationCardiomyopathiesCardiomyopathy, HypertrophicComputer SimulationFemaleHeartHumansImage EnhancementImage Interpretation, Computer-AssistedMiddle AgedMyocardial InfarctionMyocarditisfirst-pass perfusionsimultaneous multislicespiral trajectory

Identifiers

PMID30311689
PMCPMC6289615

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.