Evidence map›Paper›PMID 30311570›Full record

ReviewCritical reviews in oncogenesis2018

Current State of Knowledge on Salivary Gland Cancers.

H Helen Lin, Kirsten H Limesand, David K Ann

Abstract readReview
In one paragraph

Review in Critical reviews in oncogenesis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Guideline
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  16. Review
  17. Serum Level of Vitamin D in Patients with Salivary Gland Tumors.Iranian journal of otorhinolaryngology · 2023
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

H Helen LinDepartment of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010.
Kirsten H LimesandDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ 85712.
David K AnnDepartment of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010.
City of Hope · USUniversity of Arizona · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSIONR01DE010742 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANN, DAVID K. · 1993 to 2013
$5.1M
Mechanisms for Salivary Tumor Epithelial-Mesenchymal TransitionsR01DE026304 · NIDCR · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., LIN, HER HELEN · 2016 to 2020
$2.1M
Functional restoration through salivary progenitor label retaining cellsR01DE023534 · NIDCR · UNIVERSITY OF ARIZONA · PI ANN, DAVID K., LIMESAND, KIRSTEN H · 2014 to 2018
$1.9M
FLOAT System to Study Salivary Gland Cancer InvasionR21DE027713 · NIDCR · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K., LIN, HER HELEN · 2018 to 2019
$476k
Molecular Characterization of Autophagy in Salivary Gland TumorsR21DE023298 · NIDCR · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ANN, DAVID K. · 2013 to 2014
$462k
NCI NIH HHS P30 CA033572NIDCR NIH HHS R01 DE010742NIDCR NIH HHS R01 DE023534NIDCR NIH HHS R01 DE026304NIDCR NIH HHS R21 DE023298NIDCR NIH HHS R21 DE027713
6 · The paper itself

Abstract

Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute about 6% of head and neck cancer diagnoses based on estimate by American Head and Neck Society. Salivary gland tumors originate from different glandular cell types and are thus morphologically diverse. These tumors arise from any of the three major and various minor salivary glands. The incidence of SGCs has slowly increased during the last four decades. The etiology of SGCs is mostly unknown; however, specific gene mutations are associated with certain types of salivary tumors. Treatment options include surgical resection, radiation therapy (RT), chemotherapy, and multimodality therapy. HNC patients treated with RT often develop xerostomia and salivary hypofunction due to damaged salivary glands. In this review, we discuss etiology of SGCs, present findings on the role of autophagy in salivary tumorigenesis, review adverse effects of radiation treatment, and examine remedies for restoration of salivary function.

Indexed as

AnimalsCombined Modality TherapyDisease Models, AnimalHumansRadiotherapySalivary Gland NeoplasmsTreatment Outcome

Identifiers

PMID30311570
PMCPMC6415949
OpenAlexW2888048953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.