Evidence map›Paper›PMID 30311465›Full record

ArticleKorean journal of ophthalmology : KJO2018

Effective Delivery of Exogenous Compounds to the Optic Nerve by Intravitreal Injection of Liposome.

Junsung Lee, Unbyeol Goh, Ji Ho Park, Sang Woo Park, Hwan Heo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of ophthalmology : KJO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Junsung LeeDepartment of Ophthalmology, Chonnam National University Hospital, Gwangju, Korea.
Unbyeol GohDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Ji Ho ParkDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Sang Woo ParkDepartment of Ophthalmology, Chonnam National University Hospital, Gwangju, Korea.
Hwan HeoDepartment of Ophthalmology, Chonnam National University Hospital, Gwangju, Korea. opheye@hanmail.net.
Chonnam National University Hospital · KRKorea Advanced Institute of Science and Technology · KRKorea Institute of Brain Science · KRNune Eye Hospital · KR

Funding

Chonnam National University 2014-2057Chonnam National University 2015-3037
6 · The paper itself

Abstract

purposeTo improve the treatment efficiency of optic nerve diseases by delivering therapeutic materials to the optic nerve directly.

methodsWe tried to optimize liposomal composition to deliver a payload to the optic nerve efficiently when it is injected intravitreally. After loading dexamethasone into this liposome, we tested the therapeutic effect of liposomes in this treatment using a murine model of ischemic optic neuropathy.

resultsOur optimized liposome can deliver its payload to the optic nerve more efficiently than other tested compositions. Moreover, dexamethasone-loaded liposomes had a significant therapeutic effect in a murine model of ischemic optic neuropathy.

conclusionsHere, we demonstrate the optimal composition of liposomes that could efficiently deliver intravitreally injected exogenous compounds to the optic nerve. We expect that the intravitreal injection of liposomes with the suggested composition would improve the delivery efficacy of therapeutic compounds to the optic nerve.

Indexed as

AnimalsDexamethasoneDisease Models, AnimalDose-Response Relationship, DrugFemaleGlucocorticoidsIntravitreal InjectionsLiposomesMiceMice, Inbred C57BLMicroscopy, ConfocalOptic NerveOptic Neuropathy, IschemicRetinal Ganglion CellsTreatment OutcomeDexamethasoneGlucocorticoidsLiposomesDrug deliveryLiposomesOptic nerveOptic nerve diseases

Identifiers

PMID30311465
PMCPMC6182217
OpenAlexW2890117211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.