ArticleHuman brain mapping2019
Quantifying the axonal pathways directly stimulated in therapeutic subcallosal cingulate deep brain stimulation.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05773755 (Deep Brain Stimulation for Treatment Resistant Depression), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Deep Brain Stimulation for Treatment Resistant Depression: Exploration of Local Field Potentials (LFPs) With the Medtronic Percept PC System
Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Field potential 1/Journal of neurophysiology · 2019Trial
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Topographical anatomy of the septum verum and its white matter connections.Scientific reports · 2024Article
- Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Aperiodic neural activity is a biomarker for depression severity.medRxiv : the preprint server for health sciences · 2023Article
- Individualized targeting is warranted in subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression: A tractography analysis.Human brain mapping · 2023Article
- Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks.NeuroImage · 2023Article
- Orientation selective stimulation with tetrahedral electrodes of the rat infralimbic cortex to indirectly target the amygdala.Frontiers in neuroscience · 2023Article
- Mitigating Mismatch Compression in Differential Local Field Potentials.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- White Matter Microstructure Associated with the Antidepressant Effects of Deep Brain Stimulation in Treatment-Resistant Depression: A Review of Diffusion Tensor Imaging Studies.International journal of molecular sciences · 2022Review
- Causal mapping of human brain function.Nature reviews. Neuroscience · 2022Review
- Circuit-Targeted Neuromodulation for Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Dynamic Oscillations Evoked by Subcallosal Cingulate Deep Brain Stimulation.Frontiers in neuroscience · 2022Article
- Subcallosal Cingulate Cortex Deep Brain Stimulation for Treatment-Resistant Depression: A Systematic Review.Frontiers in neurology · 2022Review
- White Matter Tracts Associated With Deep Brain Stimulation Targets in Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2022Review
- Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate.Frontiers in human neuroscience · 2022Article
- Variability of white matter anatomy in the subcallosal cingulate area.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from patient-specific computational models. This connectomic-based biophysical modeling strategy has proven successful in improving the clinical response to SCC DBS therapy, but the DBS models used to date have been relatively simplistic, limiting the precision of the pathway activation estimates. Therefore, we used the most detailed patient-specific foundation for DBS modeling currently available (i.e., field-cable modeling) to evaluate SCC DBS in our most recent cohort of six subjects, all of which were responders to the therapy. We quantified activation of four major pathways in the SCC region: forceps minor (FM), cingulum bundle (CB), uncinate fasciculus (UF), and subcortical connections between the frontal pole and the thalamus or ventral striatum (FP). We then used the percentage of activated axons in each pathway as regressors in a linear model to predict the time it took patients to reach a stable response, or TSR. Our analysis suggests that stimulation of the left and right CBs, as well as FM are the most likely therapeutic targets for SCC DBS. In addition, the right CB alone predicted 84% of the variation in the TSR, and the correlation was positive, suggesting that activation of the right CB beyond a critical percentage may actually protract the recovery process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.