ArticleNeurochemical research2018
Sodium Valproate Ameliorates Neuronal Apoptosis in a Kainic Acid Model of Epilepsy via Enhancing PKC-Dependent GABA
Abstract read
In one paragraph
Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular Mechanism of Compound Glycyrrhizin in Kainic Acid-Induced Epilepsy in Rat Model.Molecular biotechnology · 2026Article
- Vitamin E-valproate co-therapy attenuated oxidative stress, neuroinflammation, related cognitive deficits and neuronal damage in Cypermethrin exacerbated seizure.BMC pharmacology & toxicology · 2025Article
- Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Integrating Proteomics and Transcriptomics Reveals the Potential Pathways of Hippocampal Neuron Apoptosis in Dravet Syndrome Model Mice.International journal of molecular sciences · 2024Article
- The roles of RACK1 in the pathogenesis of Alzheimer's disease.Journal of biomedical research · 2024Article
- MicroRNAs in mouse and rat models of experimental epilepsy and potential therapeutic targets.Neural regeneration research · 2023Review
- Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation.Brain sciences · 2023Review
- The "mitochondrial stress responses": the "Dr. Jekyll and Mr. Hyde" of neuronal disorders.Neural regeneration research · 2022Review
- Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats.BMC complementary medicine and therapies · 2022Article
- Potentiating Hemorrhage in a Periadolescent Rat Model of Closed-Head Traumatic Brain Injury Worsens Hyperexcitability but Not Behavioral Deficits.International journal of molecular sciences · 2021Article
- Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy.Experimental and therapeutic medicine · 2020Article
- Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.International journal of molecular sciences · 2020Review
- From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod.Current neuropharmacology · 2020Review
- MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress.Neurochemical research · 2019Article
- Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.Neurochemical research · 2019Article
- Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death.Oxidative medicine and cellular longevity · 2019Review
- Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.International journal of biological sciences · 2019Article
- Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Qin LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Qiu-Qi LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ji-Ning JiaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Shan CaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhi-Bin WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xu WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Chao LuoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hong-Hao ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhao-Qian LiuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiao-Yuan MaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China. maoxiaoyuan2011@163.com.
Central South University · CNXiangya Hospital Central South University · CN
Funding
National Natural Science Foundation of China 81302750National Natural Science Foundation of China 81503073National Natural Science Foundation of China 81671293Natural Science Foundation of Hunan Province 2017JJ3479
Abstract
GABA is a dominant inhibitory neurotransmitter in the brain and A type GABA receptor (GABA
Indexed as
AnimalsAnticonvulsantsApoptosisEpilepsyKainic AcidMaleNeuroprotective AgentsPhosphorylationProtein Kinase CRatsRats, Sprague-DawleyReceptors, GABA-ASerineValproic AcidAnticonvulsantsGabrg2 protein, ratKainic AcidNeuroprotective AgentsProtein Kinase CReceptors, GABA-ASerineValproic AcidEpilepsyGABAAR γ2GABAergic inhibitionSerine 327 residue protein phosphorylationSodium valproate
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.