Evidence map›Paper›PMID 30310990›Full record

ArticleVirchows Archiv : an international journal of pathology2019

CIC fusion-positive sarcoma of the spermatic cord.

Felix Bremmer, Alexander Fichtner, Ralph Triefenbach, Reinhard Inniger, Peter Mayer, Laura Lukat, Philipp Ströbel, Hans Ulrich Schildhaus

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Primary cardiacPediatric investigation · 2021
    Article
  3. [Round-cell sarcomas].Der Pathologe · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Felix BremmerInstitute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany. felix.bremmer@med.uni-goettingen.de.
Alexander FichtnerInstitute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany.
Ralph TriefenbachCenter for Pathology, Cytology and Molecular Pathology, Luise-Rainer-Str. 12, 40235, Düsseldorf, Germany.
Reinhard InnigerCenter for Pathology, Cytology and Molecular Pathology, Luise-Rainer-Str. 12, 40235, Düsseldorf, Germany.
Peter MayerDepartment of Urology, Catholic Clinics Oberberg, Wohlandstraße 30, 51766, Engelskirchen, Germany.
Laura LukatInstitute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany.
Philipp StröbelInstitute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany.
Hans Ulrich SchildhausInstitute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany.
University of Göttingen · DEUniversitätsmedizin Göttingen · DE

Funding

Wilhelm Sander-Stiftung 2016.041.1
6 · The paper itself

Abstract

In addition to germ cell tumors and tumors of the sex cord stroma, the WHO classification of testis and paratesticular tumors also contains malignant soft tissue tumors. Among them, liposarcomas of the spermatic cord are the most common entities. Other mesenchymal tumors with smooth muscle, skeletal muscle, fibroblastic/myofibroblastic, or nerve sheath differentiation are rare. Ewing sarcoma is composed of uniform small round cells and typically characterized by translocations of the EWSR1 gene. In rare cases, Ewing sarcoma-like tumors lack an EWSR1 gene fusion. Some of these tumors harbor a specific CIC translocation. However, Ewing-like sarcoma has up to now never been described in the testis or spermatic cord. The present case describes the first EWSR1-negative, undifferentiated round cell sarcoma with CIC translocation of the spermatic cord. Potential differential diagnoses are discussed.

Indexed as

AdultAgedBiomarkers, TumorDiagnosis, DifferentialGene FusionHumansMaleOncogene Proteins, FusionRepressor ProteinsRNA-Binding Protein EWSSarcomaSarcoma, EwingSarcoma, Small CellSoft Tissue NeoplasmsSpermatic CordTestisBiomarkers, TumorCIC protein, humanEWSR1 protein, humanOncogene Proteins, FusionRepressor ProteinsRNA-Binding Protein EWSCIC translocationEwing-like sarcomaSpermatic cordTestis

Identifiers

PMID30310990
OpenAlexW2897694101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.