ArticlePsychopharmacology2018
Cognitive and socio-cognitive functioning of chronic non-medical prescription opioid users.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review.Drug and alcohol dependence · 2021Pooled it
- Changing Patterns of Recent Substance Use in Emerging Adulthood and Their Associations With Cognitive Functions and Mental Health.Biological psychiatry global open science · 2026Article
- Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats.Psychopharmacology · 2026Article
- The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats.Psychopharmacology · 2026Article
- The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats.Research square · 2026Article
- Endocannabinoid response to social stress in chronic non-medical prescription opioid users.Psychopharmacology · 2026Article
- Assessment of Cognitive Impairment Between Natural and Synthetic Opioid Users.Journal of pharmacy & bioallied sciences · 2026Article
- Something is not nothing: Hair-tested substance use and cognitive functions in a large community sample of young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Neurocognitive Functions Among Patients Dependent on Natural Opium: A Comparative Cross-Sectional Study.Cureus · 2025Article
- Impairment in social cognition in people with substance use disorders.Frontiers in psychiatry · 2025Article
- Article
- Endocannabinoids and related lipids linked to social exclusion in individuals with chronic non-medical prescription opioid use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The intersection of empathy and addiction.Pharmacology, biochemistry, and behavior · 2023Review
- Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs.Frontiers in neuroscience · 2023Review
- Insights into the Decontamination of Cocaine-Positive Hair Samples.Journal of analytical toxicology · 2021Article
- Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor.Journal of neurochemistry · 2021Article
- Social Information Processing in Substance Use Disorders: Insights From an Emotional Go-Nogo Task.Frontiers in psychiatry · 2021Article
- Chronic Exposure to Morphine Leads to a Reduced Affective Pain Response in the Presence of Hyperalgesia in an Animal Model of Empathy.Addiction & health · 2020Article
- Restoration of prosocial behavior in rats after heroin self-administration via chemogenetic activation of the anterior insular cortex.Social neuroscience · 2020Article
- Impaired empathy and increased anger following social exclusion in non-intoxicated opioid users.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
rationaleNon-medical prescription opioid use (NMPOU) has become a major public health issue in the USA and is also increasing in Europe. However, little is known about neuropsychological associations of NMPOU-specifically regarding social cognition, which is essential for social functioning and treatability of opioid dependence. Previous studies with heroin users and opioid-substituted patients reported deficits in various cognitive functions, but these results are likely confounded by comorbid physical and psychiatric diseases, overdose-associated hypoxia, and adulteration of street heroin. Therefore, the purpose of the present study was to investigate social and non-social cognition in a relatively pure NMPOU sample taking opioid analgesics or antitussives.
methodsWe assessed 23 individuals with NMPOU objectively confirmed by hair analyses and 29 opioid-naïve, healthy controls, employing a comprehensive neuropsychological test battery.
resultsSignificant impairments were found between NMPOU individuals and controls regarding the cognitive domains of attention (p < .01, Hedge's g = .85), declarative memory (p < .05, g = .66), and global cognitive empathy (p < .01, g = 0.99)-the latter included problems with emotion recognition from faces, voices, and complex scenes. Opioid hair concentrations transformed to morphine equivalents were negatively correlated with global cognitive empathy (r = - 0.52, p < .01), suggesting dose-dependent deficits.
conclusionIn contrast to stimulant users primarily displaying deficits in emotional empathy, opioid users showed relatively selective impairments in measures of cognitive empathy, with dose-dependent effects suggesting potential opioid-induced deficits and involvement of the opioid-system in processes of cognitive empathy. These results have important implications for future interventions of opioid dependence targeting social functioning and consequently enhancing therapy outcome and preventing relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.