Evidence map›Paper›PMID 30310864›Full record

ArticleeNeuro

Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.

Todd L Stincic, Pasha Grachev, Martha A Bosch, Oline K Rønnekleiv, Martin J Kelly

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Todd L StincicDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0001-7504-2422
Pasha GrachevDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239.
Martha A BoschDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-3023-3150
Oline K RønnekleivDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0003-1841-4386
Martin J KellyDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-8633-2510
Oregon Health & Science University · USOregon National Primate Research Center · US

Funding

Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASISR01NS038809 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY · 1999 to 2018
$6.8M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Estrogen Modulation of Bursting Activity in GnRH NeuronsR01NS043330 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI RØNNEKLEIV, OLINE KARIN · 2004 to 2019
$5.5M
NIDDK NIH HHS R01 DK068098NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS038809NINDS NIH HHS R01 NS043330
6 · The paper itself

Abstract

Energy balance is regulated by anorexigenic proopiomelanocortin (POMC) and orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons of the hypothalamic arcuate nucleus. POMC neurons make extensive projections and are thought to release both amino acid and peptide neurotransmitters. However, whether they communicate directly with NPY/AgRP neurons is debated. Initially, using single-cell RT-PCR, we determined that mouse POMC

Indexed as

Agouti-Related ProteinAnimalsbeta-EndorphinEstradiolFemaleGlutamic AcidHypothalamusMaleMiceMice, TransgenicNeuronsNeuropeptide YOptogeneticsOvariectomyPatch-Clamp TechniquesPro-OpiomelanocortinAgouti-Related Proteinbeta-EndorphinEstradiolGlutamic AcidNeuropeptide YPro-Opiomelanocortinestrogenobesitysex differencesSTX

Identifiers

PMID30310864
PMCPMC6179576
OpenAlexW2883863577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.