ArticleThe Journal of cell biology1987
gamma-Aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 225 citations in OpenAlex.
- GABA corelease guides the functional maturation of glycinergic synapses in an auditory sound localization circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses.EMBO reports · 2021Article
- The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication.Membranes · 2021Review
- GABA-Glycine Cotransmitting Neurons in the Ventrolateral Medulla: Development and Functional Relevance for Breathing.Frontiers in cellular neuroscience · 2019Article
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse.Frontiers in cellular neuroscience · 2017Article
- Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation.Nature communications · 2014Article
- Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Gephyrin: a master regulator of neuronal function?Nature reviews. Neuroscience · 2014Review
- Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments.The Journal of comparative neurology · 2014Article
- Neuronal nicotinic receptors in sleep-related epilepsy: studies in integrative biology.ISRN biochemistry · 2012Review
- Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- GABA(A) Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors.Frontiers in cellular neuroscience · 2011Article
- The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite.Frontiers in neural circuits · 2010Article
- Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction.Neuroscience and behavioral physiology · 2009Article
- Cellular transport and membrane dynamics of the glycine receptor.Frontiers in molecular neuroscience · 2009Article
- Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.Frontiers in molecular neuroscience · 2009Article
- Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex.Histochemistry and cell biology · 2008Review
- Interaction of the postsynaptic effects of glycine and GABA on spinal cord neurons in the frog Rana temporaria.Neuroscience and behavioral physiology · 2008Article
- The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distributions of terminals containing gamma-aminobutyric acid (GABA) and of endings apposed to glycine receptors were investigated cytochemically in the ventral horn of the rat spinal cord. For this purpose, a polyclonal antibody raised to recognize glutamic acid decarboxylase (GAD), a synthetic enzyme for GABA, and three monoclonal antibodies (mAb's) directed against the glycine receptor were used. Double immunofluorescence showed that, surprisingly, GAD-positive terminals are closely associated in this system with glycine receptors at all the investigated cells, most of which were spinal motoneurons. Furthermore, double labeling was performed with immunoenzymatic recognition of GAD and indirect marking of mAb's with colloidal gold. With this combined approach, it was found, at the electron microscopic level, that all GAD-positive terminals are in direct apposition with glycine receptors while, on the other hand, not all glycine receptors are in front of GABA-containing boutons. This result is not due to a cross-reactivity of mAb's with GABA receptors as shown by using as a control synapses known to use GABA as a neurotransmitter in the cerebellar cortex. Indeed, no glycine receptor immunoreactivity was detected on Purkinje cells facing basket axon terminals. However, Purkinje neurons can express glycine receptor immunoreactivity at other synaptic contacts. Assuming that the presence of postsynaptic receptors for glycine indicates that this amino acid is used for neurotransmission at a given synapse, our results strongly support the notion that GABA and glycine, two classical inhibitory transmitters, coexist at some central connections. However, such is not always the case; in the cerebellum, Golgi terminals impinging on the dendrites of granule cells are either GAD-positive or face glycine receptors, in a well-segregated manner.
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