Evidence map›Paper›PMID 30310828›Full record

ArticleEuropean journal of radiology open2018

Contrast enhancement efficacy of iodinated contrast media: Effect of molecular structure on contrast enhancement.

Kuniharu Imai, Mitsuru Ikeda, Yoshiki Satoh, Keisuke Fujii, Chiyo Kawaura, Takuya Nishimoto, Masaki Mori

Abstract read
In one paragraph

Article in European journal of radiology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Synthesis of Hafnium(IV) Polyaminoacetates.Molecules (Basel, Switzerland) · 2021
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kuniharu ImaiDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan.
Mitsuru IkedaDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan.
Yoshiki SatohDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan.
Keisuke FujiiDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan.
Chiyo KawauraDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan.
Takuya NishimotoDivision of Radiological Technology, Nagoya University Hospital, 65 Tsurumai, Showa-ku, Nagoya, 466-8560, Japan.
Masaki MoriDivision of Radiological Technology, Nagoya University Hospital, 65 Tsurumai, Showa-ku, Nagoya, 466-8560, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the contrast enhancement in DSA images based on the X-ray absorption characteristics of iodinated contrast media.

methodsWe have derived a new formula of predicting the pixel value ratio of two different contrast media and designate it as "Contrast Enhancement Ratio (CER)". In order to evaluate the accuracy of CER, we have evaluated the relationship between CER and pixel value ratio for all combinations of eleven iodinated contrast media. The non-ionic iodinated contrast media, iopamidol, iomeprol, iopromide, ioversol, iohexol, and iodixanol, were evaluated in this study. Each contrast medium was filled in the simulated blood vessel in our constructed anthropomorphic phantom, and DSA images were obtained using an angiographic imaging system. To evaluate the contrast enhancement of the contrast medium, the mean pixel value was calculated from all pixel values in the vascular image.

resultsCER was indicated to agree well with the pixel value ratio of two different contrast medium solutions and showed a good accuracy. CER was also shown to have a good linear relation to the pixel value ratio when the iodine concentration was constant. This means that the molecular structure of the contrast media affects contrast enhancement efficacy. Furthermore, in evaluation of contrast enhancement of iodinated contrast media by using the weight factor (that is a key factor in CER) ratio, Iodixanol, and iopamidol, and iomeprol have the same ability of contrast enhancement in DSA images, and iohexol shows the lowest ability.

conclusionsWe have derived a new formula (CER) of predicting the pixel value ratio of two different contrast medium solutions, and shown that CER agreed well with the pixel value ratio for blood vessel filled with eleven contrast media.

Indexed as

Contrast enhancement efficacyContrast enhancement ratioMolecular structureNon-ionic iodinated contrast media

Identifiers

PMID30310828
PMCPMC6176554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.