ArticleThe Journal of cell biology1987
Accumulation of adrenocorticotropin secretory granules in the midbody of telophase AtT20 cells: evidence that secretory granules move anterogradely along microtubules.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- 60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.Journal of molecular endocrinology · 2016Review
- Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells.International journal of cell biology · 2012Article
- Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Hydrogen-deuterium exchange effects on beta-endorphin release from AtT20 murine pituitary tumor cells.Biophysical journal · 2004Article
- Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor.Molecular biology of the cell · 2002Article
- A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Vector alkaline phophatase substrate Blue III: one substrate for brightfield histochemistry and high-resolution fluorescence imaging by confocal laser scanning microscopy.The Histochemical journal · 1998Article
- Glucocorticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotropin release.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway.Molecular biology of the cell · 1992Article
- P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells.The Journal of cell biology · 1992Article
- Characterization of the immature secretory granule, an intermediate in granule biogenesis.The Journal of cell biology · 1991Article
- GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.The EMBO journal · 1991Article
- Cell cycle control of microtubule-based membrane transport and tubule formation in vitro.The Journal of cell biology · 1991Article
- Membrane traffic between secretory compartments is differentially affected during mitosis.Cell regulation · 1990Article
- The response of the Golgi complex to microtubule alterations: the roles of metabolic energy and membrane traffic in Golgi complex organization.The Journal of cell biology · 1989Article
- Spatial segregation of the regulated and constitutive secretory pathways.The Journal of cell biology · 1989Article
- Interactions of cytoplasmic granules with microtubules in human neutrophils.The Journal of cell biology · 1989Article
- Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts.The Journal of cell biology · 1989Article
- Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.The Journal of cell biology · 1989Article
- The cell biology of the nerve terminal.Neuron · 1988Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the cell cycle the distribution of the ACTH-containing secretory granules in AtT20 cells, as revealed by immunofluorescence labeling and electron microscopy of thin sections, undergoes a cycle of changes. In interphase cells the granules are concentrated in the Golgi region, where they form, and also at the tips of projections from the cells, where they accumulate. These projections contain many microtubules extending to their tips. During metaphase and anaphase the granules are randomly distributed in the cytoplasm of the rounded-up mitotic cells. On entry into telophase there is a rapid and striking redistribution of the granules, which accumulate in large numbers in the midbody as it develops during cytokinesis. This accumulation of secretory granules in the midbody is dependent upon the presence of microtubules. The changing pattern of distribution of the secretory granules during the cell cycle fulfills the predictions of a model envisaging first that secretory granules associate with and move along interphase microtubules in a net anterograde direction away from the centrioles, and secondly that they do not associate with microtubules of the mitotic spindle during metaphase and anaphase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.