Evidence map›Paper›PMID 30310789›Full record

ArticleBlood research2018

Bendamustine, etoposide, and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in non-Hodgkin lymphoma.

Adam M Greenbaum, Damian J Green, Leona A Holmberg, Ted Gooley, Brian G Till, Lihua E Budde, Heather Rasmussen, Oliver W Press, Ajay K Gopal

Open access · diamondAbstract read
In one paragraph

Article in Blood research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Adam M GreenbaumClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Damian J GreenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Leona A HolmbergClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ted GooleyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Brian G TillClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lihua E BuddeDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.
Heather RasmussenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Oliver W PressClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ajay K GopalClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Fred Hutch Cancer Center · USCity Of Hope National Medical Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
TREATMENT OF B-CELL LYMPHOMAP01CA044991 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRESS, OLIVER W. · 1988 to 2015
$29.3M
TRAINING IN CANCER BIOLOGY &TRANSPLANTATIONT32CA009515 · NCI · UNIVERSITY OF WASHINGTON · PI NANCY ELLEN DAVIDSON, Effie W Petersdorf · 1985 to 2026
$16.2M
Radioimmunotherapy Combinations for B-cell MalignancyR01CA076287 · NCI · UNIVERSITY OF WASHINGTON · PI GREEN, DAMIAN J. · 1998 to 2025
$8.1M
Bone Marrow Transplantation for Hematologic Malignancies using Novel RadioimmunotR01CA138720 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRESS, OLIVER W. · 2010 to 2014
$1.9M
Molecularly Targeted Therapy for LymphomaK24CA184039 · NCI · UNIVERSITY OF WASHINGTON · PI GOPAL, AJAY · 2014 to 2018
$866k
Radioimmunotherapy for Multiple MyelomaK08CA151682 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GREEN, DAMIAN J. · 2010 to 2014
$848k
NCI NIH HHS K08 CA151682NCI NIH HHS K24 CA184039NCI NIH HHS P01 CA044991NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA076287NCI NIH HHS R01 CA138720NCI NIH HHS T32 CA009515
6 · The paper itself

Abstract

backgroundBendamustine is a chemotherapeutic agent that has shown broad activity in patients with lymphoid malignancies. It contains both alkylating and nucleoside analog moieties, and thus, is not commonly used for stem cell mobilization due to concerns that it may adversely affect stem cell collection. Here we describe the lymphoma subset of a prospective, non-randomized phase II study of bendamustine, etoposide, and dexamethasone (BED) as a mobilization agent for lymphoid malignancies.

methodsThis subset analysis includes diffuse large B-cell lymphoma (N=3), follicular lymphoma (N=1), primary mediastinal B-cell lymphoma (N=1), and NK/T-cell lymphoma (N=1). Patients received bendamustine (120 mg/m

resultsWe successfully collected stem cells from all patients, with a median of 7.9×10

conclusionFor non-Hodgkin lymphoma, mobilization with bendamustine is safe and effective.

Indexed as

BendamustineNon-Hodgkin lymphomaStem cell mobilization

Identifiers

PMID30310789
PMCPMC6170297
OpenAlexW2895634296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.