Evidence map›Paper›PMID 30310655›Full record

ArticleToxicology research2018

Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs.

Imdad Ali, Muhammad Raza Shah, Sammer Yousuf, Shakil Ahmed, Kiramat Shah, Ibrahim Javed

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Imdad AliH.E.J. Research Institute of Chemistry , International Center for Chemical and Biological Sciences , University of Karachi , Karachi 74200 , Pakistan . Email: raza.shah@iccs.edu.
Muhammad Raza ShahH.E.J. Research Institute of Chemistry , International Center for Chemical and Biological Sciences , University of Karachi , Karachi 74200 , Pakistan . Email: raza.shah@iccs.edu.ORCID 0000-0003-4978-3627
Sammer YousufH.E.J. Research Institute of Chemistry , International Center for Chemical and Biological Sciences , University of Karachi , Karachi 74200 , Pakistan . Email: raza.shah@iccs.edu.ORCID 0000-0002-8870-3581
Shakil AhmedH.E.J. Research Institute of Chemistry , International Center for Chemical and Biological Sciences , University of Karachi , Karachi 74200 , Pakistan . Email: raza.shah@iccs.edu.
Kiramat ShahH.E.J. Research Institute of Chemistry , International Center for Chemical and Biological Sciences , University of Karachi , Karachi 74200 , Pakistan . Email: raza.shah@iccs.edu.ORCID 0000-0002-2635-665X
Ibrahim JavedARC Centre of Excellence in Convergent Bio-Nano Science and Technology , Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia . Email: ibrahim.javed@monash.edu.ORCID 0000-0003-1101-5614
University of Karachi · PKAustralian Regenerative Medicine Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biocompatible surfactants are of diverse pharmaceutical interest due to their ability to self-assemble into nano-particulate systems which can be used for single-step drug loading, based upon the hydrophobic-hydrophobic interaction between a hydrophobic drug and the lipophilic part of a surfactant molecule. However, surfactants are associated with cytotoxicity and hemolysis due to their amphiphilic interaction with cellular membranes. This study reports a novel membrane-compatible surfactant, synthesized from sulfanilamide and its self-micellization into niosomes. The surfactant was synthesized in a single step reaction

Identifiers

PMID30310655
PMCPMC6116827
OpenAlexW2808361672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.