Evidence map›Paper›PMID 30310579›Full record

ArticleChemical science2018

Exploration of biocompatible AIEgens from natural resources.

Yuan Gu, Zheng Zhao, Huifang Su, Pengfei Zhang, Junkai Liu, Guangle Niu, Shiwu Li, Zhaoyang Wang, Ryan T K Kwok, Xin-Long Ni and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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  10. Review
  11. Article
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  13. Natural Acceptor of Coumarin-Isomerized Red-Emissive BioAIEgen for Monitoring CuAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  14. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuan GuDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.
Zheng ZhaoDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.ORCID 0000-0002-5536-0439
Huifang SuDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.
Pengfei ZhangDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.ORCID 0000-0003-0390-3806
Junkai LiuNSFC Center for Luminescence from Molecular Aggregate , SCUT-HKUST Joint Research Laboratory , State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , China.
Guangle NiuDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.ORCID 0000-0002-5403-6880
Shiwu LiNSFC Center for Luminescence from Molecular Aggregate , SCUT-HKUST Joint Research Laboratory , State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , China.
Zhaoyang WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization , Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.
Ryan T K KwokDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.
Xin-Long NiMOE Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province , Guizhou University , Guiyang , Guizhou 550025 , China.ORCID 0000-0002-5557-1631
Jingzhi SunMOE Key Laboratory of Macromolecular Synthesis and Functionalization , Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.ORCID 0000-0001-5478-5841
Anjun QinNSFC Center for Luminescence from Molecular Aggregate , SCUT-HKUST Joint Research Laboratory , State Key Laboratory of Luminescent Materials and Devices , South China University of Technology , Guangzhou 510640 , China.ORCID 0000-0001-7158-1808
Jacky W Y LamDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.
Ben Zhong TangDepartment of Chemistry , Department of Chemical and Biological Engineering , Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , Institute for Advanced Study , Division of Biomedical Engineering , Division of Life Science and State Key Laboratory of Molecular Neuroscience , The Hong Kong University of Science and Technology (HKUST) , Clear Water Bay , Kowloon , China . Email: tangbenz@ust.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luminogens with aggregation-induced emission (AIEgens) characteristics have been well developed and applied in various areas such as bio-imaging, theranostics, organic photoelectronics and chemo/bio sensors. However, most of the reported AIEgens suffer from the disadvantages of complex organic synthesis and high cost, as well as being environmentally unfriendly and hard to degrade, which have largely limited their real applications. In this work, we discovered berberine chloride, a natural isoquinoline alkaloid isolated from Chinese herbal plants, as an unconventional rotor-free AIEgen with bright solid-state emission and water-soluble characteristics. Single crystal structure analysis and optical property, viscosity, and host-guest interaction studies suggested that intramolecular vibration and twisted intramolecular charge transfer were responsible for the AIE phenomenon of berberine chloride. Moreover, berberine chloride was biocompatible and could specifically target lipid droplets in a fluorescence turn-on and wash-free manner, demonstrating the great potential of natural products as promising AIE probes.

Identifiers

PMID30310579
PMCPMC6115644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.