ArticleScientific reports2018
Novel Classification of Early-stage Systemic Hypertensive Changes in Human Retina Based on OCTA Measurement of Choriocapillaris.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 69 citations in OpenAlex.
- [The eye as a mirror of the heart-retinal findings in heart failure and cardiovascular diseases].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Involvement of best-corrected visual acuity in sarcopenia: findings from baseline analysis of the Kyotango longevity cohort study.Japanese journal of ophthalmology · 2026Article
- Adaptive Optics RTX1 Imaging for Early Detection of Retinal Vascular Remodeling in Hypertensive Retinopathy: A Review.Journal of clinical medicine · 2026Review
- Retinal Dysfunction in Hypertensive Patients with Atherosclerotic Plaque Detected by Carotid Doppler Ultrasound: An Optical Coherence Tomography Angiography Assessment.Life (Basel, Switzerland) · 2026Article
- Evaluating the effect of systemic hypertension on retinal, optic nerve head microvasculature and field of vision using optical coherence tomography angiography and visual field analyzer.BMC ophthalmology · 2025Observational
- Optical Coherence Tomography Angiography Is Associated with Disease Activity Expressed by NEDA-3 Status in Patients with Relapsing Multiple Sclerosis.Journal of clinical medicine · 2025Article
- Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.Eye (London, England) · 2025Review
- The Relevance of Optical Coherence Tomography Angiography in Screening and Monitoring Hypertensive Patients with Carotid Artery Stenosis.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study.European journal of medical research · 2025Observational
- Retinal vascular alterations as assessment indicators of atherosclerotic cardiovascular disease risk in dyslipidemia patients.Frontiers in cardiovascular medicine · 2025Article
- Using deep learning to screen OCTA images for hypertension to reduce the risk of serious complications.Frontiers in cell and developmental biology · 2025Article
- Monitoring Progression in Hypertensive Patients with Dyslipidemia Using Optical Coherence Tomography Angiography: Can A.I. Be Improved?Journal of clinical medicine · 2024Article
- Assessment of the impact of low-density lipoprotein cholesterol on retinal vessels using optical coherence tomography angiography.Lipids in health and disease · 2024Article
- Non-Invasive Retinal Vessel Analysis as a Predictor for Cardiovascular Disease.Journal of personalized medicine · 2024Review
- The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels.Scientific reports · 2023Article
- Modifications in ocular microperfusion after transcatheter aortic valve implantation.Scientific reports · 2023Article
- Evaluation of subclinical changes in recently diagnosed pediatric hypertension patients without hypertensive retinopathy: an OCT study.International ophthalmology · 2023Article
- Comparison of the Relationship between Visual Acuity and Motor Function in Non-Elderly and Elderly Adults.Journal of clinical medicine · 2023Article
- The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis.BioMed research international · 2023Article
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Authors and funding
13 authors at 2 institutions in 1 country.
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Abstract
The traditional classification of hypertensive retinopathy was based on the Keith-Wagener-Barker (KWB) grading, which is a subjective scaling system, and it is difficult to distinguish between the first and second grades. Retinal and choroidal vasculatures are affected by systemic hypertension, although retinal vasculature changes with age, axial length, intraocular pressure, and retinal diseases. It is necessary to establish a new objective method to assess hypertensive vascular changes. In the present study, we have examined the vasculature of the macular choriocapillaris in order to establish a new objective method to assess hypertensive vascular changes using optical coherence tomography angiography (OCTA). Choriocapillaris vessel density (VD), vessel length, and vessel diameter index in a 3 × 3 mm macular area were measured by OTCA in a total of 567 volunteers (361 healthy subjects and 206 subjects with systemic hypertension) who attended a basic health check-up. Ocular factors, systemic factors, and medications were evaluated. We detected significant differences in normative choriocapillaris vasculature between the left and right eyes in 53 healthy subjects and revealed correlations between age, intraocular pressure, axial length, and choriocapillaris vasculature in 308 healthy subjects. Normative foveal VD was correlated with age only and the efficiency was weak. The analysis of 206 right eyes (KWB grade 0, 159 eyes; grade 1, 35 eyes; and grade 2, 12 eyes) revealed that foveal VD was strongly correlated with KWB grade only (P < 0.001). This is the first report suggesting that OCTA for foveal choriocapillaris measurement by OCTA would might provide the advantage of evaluating be objective method for evaluating the progression of systemic hypertension.
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