ArticleScientific reports2018
Heat-stress triggers MAPK crosstalk to turn on the hyperosmotic response pathway.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- HOG Signaling: A Multifunctional Regulator of Stress Homeostasis inJournal of fungi (Basel, Switzerland) · 2026Review
- Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions.Nucleic acids research · 2026Article
- Characterization of novel lncRNA adrenal expression profiles in response to heat stress in rats.Functional & integrative genomics · 2026Article
- Effect of the biomass production conditions on survival of the probiotic yeast Saccharomyces cerevisiae var. boulardii in a laboratory model of the gastrointestinal tract.Microbial cell factories · 2026Article
- Surprising regulatory plasticity for the conserved HOG pathway in diversebioRxiv : the preprint server for biology · 2025Article
- Special Issue "Genetic Engineering of Plants for Stress Tolerance".International journal of molecular sciences · 2025Article
- Transcriptome analysis of two rice cultivars highlights the role of auxin- and JA-responsive genes under heat stress.BMC genomics · 2025Article
- Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici.G3 (Bethesda, Md.) · 2025Article
- Thermotolerant yeasts promoting climate-resilient bioproduction.FEMS yeast research · 2025Review
- The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses inFrontiers in cell and developmental biology · 2025Review
- RNA-seq reveals changes in the transcriptome of the breast muscle of adult female chickens in response to heat stress.BMC genomics · 2024Article
- Engineering of Aspergillus niger for efficient production of D-xylitol from L-arabinose.Microbial cell factories · 2024Article
- Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis inJournal of fungi (Basel, Switzerland) · 2024Article
- Pituitary transcriptome profile from laying period to incubation period of Changshun green-shell laying hens.BMC genomics · 2024Article
- Data integration strategies for whole-cell modeling.FEMS yeast research · 2024Review
- Investigation of cold-resistance mechanisms in cryophylactic yeastFrontiers in microbiology · 2024Article
- Yeast lacking the sterol C-5 desaturase Erg3 are tolerant to the anti-inflammatory triterpenoid saponin escin.Scientific reports · 2023Article
- Hog1-mediated stress tolerance in the pathogenic fungus Trichosporon asahii.Scientific reports · 2023Article
- MAP Kinase FgHog1 and Importin β FgNmd5 Regulate Calcium Homeostasis inJournal of fungi (Basel, Switzerland) · 2023Article
- Caffeine activates HOG-signalling and inhibits pseudohyphal growth in Saccharomyces cerevisiae.BMC research notes · 2023Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells make decisions based on a combination of external and internal signals. In yeast, the high osmolarity response (HOG) is a mitogen-activated protein kinase (MAPK) pathway that responds to a variety of stimuli, and it is central to the general stress response. Here we studied the effect of heat-stress (HS) on HOG. Using live-cell reporters and genetics, we show that HS promotes Hog1 phosphorylation and Hog1-dependent gene expression, exclusively via the Sln1 phosphorelay branch, and that the strength of the activation is larger in yeast adapted to high external osmolarity. HS stimulation of HOG is indirect. First, we show that HS causes glycerol loss, necessary for HOG activation. Preventing glycerol efflux by deleting the glyceroporin FPS1 or its regulators RGC1 and ASK10/RGC2, or by increasing external glycerol, greatly reduced HOG activation. Second, we found that HOG stimulation by HS depended on the operation of a second MAPK pathway, the cell-wall integrity (CWI), a well-known mediator of HS, since inactivating Pkc1 or deleting the MAPK SLT2 greatly reduced HOG activation. Our data suggest that the main role of the CWI in this process is to stimulate glycerol loss. We found that in yeast expressing the constitutively open channel mutant (Fps1-Δ11), HOG activity was independent of Slt2. In summary, we suggest that HS causes a reduction in turgor due to the loss of glycerol and the accompanying water, and that this is what actually stimulates HOG. Thus, taken together, our findings highlight a central role for Fps1, and the metabolism of glycerol, in the communication between the yeast MAPK pathways, essential for survival and reproduction in changing environments.
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