ArticleNature communications2018
Generation of orthotopically functional salivary gland from embryonic stem cells.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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Who cites it
80 citing papers in PubMed.
- A Mouthful of Genomic Data: Single-Cell Insights into Salivary Gland Biology and Disease.Biology · 2026Review
- First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia.Regenerative therapy · 2026Article
- Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.Cell reports. Medicine · 2026Article
- Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands.Regenerative therapy · 2025Article
- Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages.Nature communications · 2025Article
- Human iPSC-derived salivary gland cell sheets integrate with injured glands to form glandular structures.Stem cell reports · 2025Article
- Organoid-based modeling and regenerative strategies for salivary gland dysfunction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Review
- Article
- Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction.bioRxiv : the preprint server for biology · 2025Article
- Oral tissue spheroid, organoid, and organ-on chip microphysiological modeling strategies towards enhanced emulation of health and disease.Bioengineering & translational medicine · 2025Review
- Organoid in dentistry: Models for oral biology and disease.Journal of dental sciences · 2025Review
- Application of Gene Therapy to Oral Diseases.Pharmaceutics · 2025Review
- Three-dimensional in vitro models in head and neck cancer: current trends and applications.Medical oncology (Northwood, London, England) · 2025Review
- Surgical considerations towards inducing proprioceptive feedback in dental implants.Scientific reports · 2025Article
- Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary Sjögren's syndrome.Journal of translational autoimmunity · 2024Article
- Organoids in the oral and maxillofacial region: present and future.International journal of oral science · 2024Review
- A Decade of Organoid Research: Progress and Challenges in the Field of Organoid Technology.ACS omega · 2024Review
- Exploring the Cocktail Factor Approach to Generate Salivary Gland Progenitors through Co-Culture Techniques.Tissue engineering and regenerative medicine · 2024Article
- Salivary Gland Tissue Recombination Can Modify Cell Fate.Journal of dental research · 2024Article
- Generation of salivary glands derived from pluripotent stem cells via conditional blastocyst complementation.Cell reports · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of organogenesis. These processes are strictly regulated by morphogen signalling and transcriptional networks. However, the precise transcription factors involved in the organogenesis of exocrine glands, including salivary glands, remain unknown. Here, we identify a specific combination of two transcription factors (Sox9 and Foxc1) responsible for the differentiation of mouse embryonic stem cell-derived oral ectoderm into the salivary gland rudiment in an organoid culture system. Following orthotopic transplantation into mice whose salivary glands had been removed, the induced salivary gland rudiment not only showed a similar morphology and gene expression profile to those of the embryonic salivary gland rudiment of normal mice but also exhibited characteristics of mature salivary glands, including saliva secretion. This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
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