Evidence map›Paper›PMID 30309983›Full record

ArticleThe Journal of biological chemistry2018

Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly.

Jiri Vlach, Gunnar N Eastep, Ruba H Ghanam, Susan M Watanabe, Carol A Carter, Jamil S Saad

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  5. Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiri VlachFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and.
Gunnar N EastepFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and.
Ruba H GhanamFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and.
Susan M Watanabethe Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794.
Carol A Carterthe Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794.
Jamil S SaadFrom the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and saad@uab.edu.ORCID 0000-0001-9503-6484
University of Alabama at Birmingham · USStony Brook University · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
800 MHz NMR Spectrometer for the Central Alabama High-Field NMR FacilityS10RR022994 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNA, NEPALLI RAMA · 2009 to 2009
$2.0M
Cellular Protein Involved in Trafficking of HIV-1R01GM111028 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI CARTER, CAROL A · 2013 to 2019
$2.0M
Structural Basis for HIV-1 Gag Interactions with Cellular ConstituentsR01GM117837 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAD, JAMIL SUBHI · 2015 to 2018
$1.7M
Cellular Protein Involved in Trafficking of HIV-1R01AI150489 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI CARTER, CAROL A · 2020 to 2022
$1.2M
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR022994NIAID NIH HHS R01 AI150489NIGMS NIH HHS R01 GM111028NIGMS NIH HHS R01 GM117837
6 · The paper itself

Abstract

For most retroviruses, including HIV-1, binding of the Gag polyprotein to the plasma membrane (PM) is mediated by interactions between Gag's N-terminal myristoylated matrix (MA) domain and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Indexed as

AcylationAvian Sarcoma VirusesBinding SitesCell MembraneGene Products, gagInositol PhosphatesLiposomesPeptide FragmentsPhosphatidylinositolsPhosphatidylserinesProtein BindingProtein DomainsStatic ElectricityVirus AssemblyGene Products, gagInositol PhosphatesLiposomesPeptide FragmentsPhosphatidylinositolsPhosphatidylserinesASVavian sarcoma virusGag proteinhuman immunodeficiency virus (HIV)inositol hexakisphosphateisothermal titration calorimetry (ITC)liposomemyristoylated matrixphosphatidylinositol 4,5-bisphosphatephosphatidylserineplasma membrane

Identifiers

PMID30309983
PMCPMC6295720
OpenAlexW2895899729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.