Evidence map›Paper›PMID 30309978›Full record

SynthesisThe European respiratory journal2018

Matching-adjusted indirect comparison of benralizumab

Arnaud Bourdin, Don Husereau, Nicolas Molinari, Sarowar Golam, Mohd Kashif Siddiqui, Leandro Lindner, Xiao Xu

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  5. Matching-adjusted comparison of oral corticosteroid reduction in asthma: Systematic review of biologics.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020
    Pooled it
  6. Trial
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  17. Unanswered questions on the use of biologics in pediatric asthma.The World Allergy Organization journal · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 6 countries.

Arnaud BourdinDept of Respiratory Diseases, Montpellier University Hospitals, Arnaud de Villeneuve Hospital, Montpellier, France.
Don HusereauInstitute of Health Economics, Edmonton, AB, Canada.
Nicolas MolinariIMAG, CNRS, University of Montpellier, CHU Montpellier, Montpellier, France.
Sarowar GolamAstraZeneca, Gothenburg, Sweden.
Mohd Kashif SiddiquiPAREXEL International Ltd, Chandigarh, India.
Leandro LindnerAstraZeneca, Barcelona, Spain.
Xiao XuAstraZeneca, Gaithersburg, MD, USA.
AstraZeneca (Spain) · ESAstraZeneca (Sweden) · SEAstraZeneca (United States) · USHôpital Arnaud de Villeneuve · FRPAREXEL International (India) · INUniversité de Montpellier · FRUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that directly depletes eosinophils. Its relative efficacy

Indexed as

Anti-Asthmatic AgentsAntibodies, Monoclonal, HumanizedAsthmaComparative Effectiveness ResearchDisease ProgressionHumansInjections, SubcutaneousInterleukin-5Quality of LifeRandomized Controlled Trials as TopicReceptors, Interleukin-5Treatment OutcomeAnti-Asthmatic AgentsAntibodies, Monoclonal, HumanizedbenralizumabInterleukin-5Receptors, Interleukin-5

Identifiers

PMID30309978
PMCPMC6277255
OpenAlexW2897328042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.