ArticleProceedings of the National Academy of Sciences of the United States of America2018
Thermodynamic favorability and pathway yield as evolutionary tradeoffs in biosynthetic pathway choice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources.mSystems · 2025Article
- Improving pathway prediction accuracy of constraints-based metabolic network models by treating enzymes as microcompartments.Synthetic and systems biotechnology · 2023Article
- Reconstruction of the last bacterial common ancestor from 183 pangenomes reveals a versatile ancient core genome.Genome biology · 2023Article
- Path to improving the life cycle and quality of genome-scale models of metabolism.Cell systems · 2021Review
- The Expanding Computational Toolbox for Engineering Microbial Phenotypes at the Genome Scale.Microorganisms · 2020Review
- Article
- Linking metabolic phenotypes to pathogenic traits among "Candidatus Liberibacter asiaticus" and its hosts.NPJ systems biology and applications · 2020Article
- Article
- Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN.Nature communications · 2020Article
- Dynamic resource allocation drives growth under nitrogen starvation in eukaryotes.NPJ systems biology and applications · 2020Article
- Environmental stimuli drive a transition from cooperation to competition in synthetic phototrophic communities.Nature microbiology · 2019Article
- Multiscale Multiobjective Systems Analysis (MiMoSA): an advanced metabolic modeling framework for complex systems.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure of the metabolic network contains myriad organism-specific variations across the tree of life, but the selection basis for pathway choices in different organisms is not well understood. Here, we examined the metabolic capabilities with respect to cofactor use and pathway thermodynamics of all sequenced organisms in the Kyoto Encyclopedia of Genes and Genomes Database. We found that (
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Registered trials
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