Evidence map›Paper›PMID 30309944›Full record

ReviewScience (New York, N.Y.)2018

Neuronal specification in space and time.

Isabel Holguera, Claude Desplan

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Temporal neuronal differentiation programs safeguard neuronal diversity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Emerging tools to advance neuroethology in butterflies and moths.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  15. Article
  16. Article
  17. Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  18. Article
  19. Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026
    Article
  20. Review

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabel HolgueraDepartment of Biology, New York University, New York, NY 10003, USA.ORCID 0000-0003-2796-6596
Claude DesplanDepartment of Biology, New York University, New York, NY 10003, USA. cd38@nyu.edu.

Funding

Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY013012
6 · The paper itself

Abstract

To understand how neurons assemble to form functional circuits, it is necessary to obtain a detailed knowledge of their diversity and to define the developmental specification programs that give rise to this diversity. Invertebrates and vertebrates appear to share common developmental principles of neuronal specification in which cascades of transcription factors temporally pattern progenitors, while spatial cues modify the outcomes of this temporal patterning. Here, we highlight these conserved mechanisms and describe how they are used in distinct neural structures. We present the questions that remain for a better understanding of neuronal specification. Single-cell RNA profiling approaches will potentially shed light on these questions, allowing not only the characterization of neuronal diversity in adult brains, but also the investigation of the developmental trajectories leading to the generation and maintenance of this diversity.

Indexed as

Neural PathwaysAnimalsCell CountCell DivisionMiceNeural Stem CellsNeuronsOrgan SpecificitySingle-Cell AnalysisSomatosensory Cortex

Identifiers

PMID30309944
PMCPMC6368964

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.