ArticleHaematologica2019
Association of anemia with health-related quality of life and survival: a large population-based cohort study.
Article in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Particulate Matter 2.5 and Hematological Disorders From Dust to Diseases: A Systematic Review of Available Evidence.Frontiers in medicine · 2021Pooled it
- Hemoglobinometry at the point of care with activation of a hospital transfusion pathway versus usual care for the early detection of anaemia in primary care: the ANHEMOG randomized controlled trial.BMC primary care · 2026Trial
- The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial.Blood advances · 2024Trial
- First-time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing.Transfusion medicine (Oxford, England) · 2026Article
- Development of an anemia detection model in emergency departments using lip region images based on medical knowledge and deep learning technology.Scientific reports · 2026Article
- Article
- Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing.Leukemia · 2026Article
- Hemoglobin predicts mortality risk in geriatric patients with dysphagia: a Japanese retrospective cohort study.Frontiers in nutrition · 2026Article
- Long-term trends in anemia prevalence before and after COVID-19 among non-pregnant adults in South Korea, 2010 to 2023.Medicine · 2025Article
- Associations of serum iron and its status change with mortality risk: prospective findings from the MJ cohort.European journal of epidemiology · 2025Article
- Anaemia of inflammation and cancer risk according to comorbidity in patients aged 40-89 years: a Danish cohort study.BMC cancer · 2025Observational
- The prevalence and etiology of anemia and the association between anemia and all-cause mortality: a cohort study over a 9-year period.BMC geriatrics · 2025Article
- Addressing Anemia in High-Altitude Populations: Global Impact, Prevalence, Challenges, and Potential Solutions.American journal of hematology · 2025Review
- Prognostic Value of Preoperative Hemoglobin in Patients Undergoing Radical Prostatectomy for Localized Prostate Cancer.Cancers · 2025Article
- Magnitude and determinants of anemia among patients at Garbo Primary Hospital, Somali Region of Ethiopia.Scientific reports · 2025Article
- Iron, Emotion, and Awareness: Exploring Alexithymia and Anxiety in Anemic Women.Medicina (Kaunas, Lithuania) · 2025Article
- The Efficacy and Safety of a Personalized Protocol Designed to Balance Hemoglobin Levels in Hemodialysis Patients as Led by Nephrology Clinical Nurse Specialists: An Intervention Study.Healthcare (Basel, Switzerland) · 2025Article
- Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep-Breathing Monitoring Index.Clinical and translational science · 2025Article
- Preoperative ANemiA among elderly undergoing Major Abdominal surgery (PANAMA) is associated with early postoperative morbidity and worse quality of life outcomes.Scientific reports · 2025Observational
- Impact of hand grip strength reduce on health related quality of life in patients with transfusion-dependent thalassemia insights from the SF-36 survey: a cross-sectional analysis.Frontiers in medicine · 2025Article
21 more citing papers are in PubMed but not listed here.
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7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have not been conclusive. We investigated these issues using survival data, scores from a health-related quality of life questionnaire (RAND-36), and hemoglobin concentration from 138670 subjects, aged 18-93 years, participating in the Lifelines cohort. Anemia was defined according to World Health Organization criteria and was further subclassified in participants over 60 years old. Anemia was present in 5510 (4.0%) of all 138670 subjects and 516 (2.8%) in the 18667 individuals older than 60 years. Anemia had no impact on overall survival and limited impact on health-related quality of life in individuals less than 60 years old. In contrast, in individuals over 60 years old anemia significantly impaired overall survival and health-related quality of life. The lower health-related quality of life was mainly observed in subscales representing physical functioning. Although consensus on the subclassification of anemia is lacking, our data suggest that particularly anemia of chronic inflammation was associated with worse overall survival and decreased health-related quality of life. Multivariate models confirmed that anemia was an independent risk factor for decreased health-related quality of life in older individuals. Finally, women with a hemoglobin concentration between 12.0-13.0 g/dL (considered anemia in men, but not in women) experienced a significantly lower health-related quality of life. This large, prospective, population-based study indicates that anemia is associated with worse overall survival and health-related quality of life in older individuals, but not in younger individuals. The findings of this study challenge the definition of anemia in women over 60 years old, and suggest that the optimal definition of anemia, in the perspective of health-related quality of life, in women over 60 years old should be altered to a hemoglobin concentration below 13.0 g/dL (8.0 mmol/L), which is comparable to that in men.
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