Evidence map›Paper›PMID 30309843›Full record

ArticleAJNR. American journal of neuroradiology2018

MR Venous Flow in Sigmoid Sinus Diverticulum.

M R Amans, H Haraldsson, E Kao, S Kefayati, K Meisel, R Khangura, J Leach, N D Jani, F Faraji, M Ballweber and 2 more

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Endovascular vs surgical treatment of sigmoid sinus diverticulum causing pulsatile tinnitus: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Pooled it
  2. Evaluation of sigmoid sinus hemodynamics through four-dimensional flow magnetic resonance imaging in pulsatile tinnitus patients caused by sigmoid sinus wall dehiscence coexisting with idiopathic intracranial hypertension.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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  5. Endovascular treatment of sigmoid Sinus diverticulum in patients with pulsatile tinnitus.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  6. Systematic Review of the Diagnostic Imaging Evaluation of Pulsatile Tinnitus.medRxiv : the preprint server for health sciences · 2025
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  10. Study on the correlation between hemodynamic status of the transverse sinus-sigmoid sinus and the clinical efficacy of sigmoid sinus wall reconstruction.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

M R AmansFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.) matthew.amans@ucsf.edu.ORCID 0000-0002-8209-0534
H HaraldssonFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0003-2363-2994
E KaoFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0003-2975-3690
S KefayatiFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0002-6941-5330
K MeiselNeurology (K.M., W.S.), University of California, San Francisco, San Francisco, California.ORCID 0000-0003-4938-2495
R KhanguraFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0002-5187-0634
J LeachFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0002-6800-0790
N D JaniFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0001-6535-0982
F FarajiFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0003-3218-1347
M BallweberFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0002-6770-9984
W SmithNeurology (K.M., W.S.), University of California, San Francisco, San Francisco, California.ORCID 0000-0003-4174-8333
D SalonerFrom the Departments of Radiology and Biomedical Imaging (M.R.A., H.H., E.K., S.K., R.K., J.L., N.D.J., F.F., M.B., D.S.).ORCID 0000-0002-6989-8547
Norwegian Womens Public Health Association · NOUniversity of California, San Francisco · USJohnson Matthey (Germany) · DE

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Improved durability of sinus stenting for idiopathic intracranial hypertension using advanced MR flow analysisR56HL149124 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMANS, MATTHEW · 2019 to 2019
$555k
MR Imaging of Blood Flow in Pulsatile TinnitusR21DC016087 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMANS, MATTHEW, SALONER, DAVID A · 2017 to 2018
$436k
NCATS NIH HHS UL1 TR001872NHLBI NIH HHS R56 HL149124NIDCD NIH HHS R21 DC016087
6 · The paper itself

Abstract

background and purposeCase reports demonstrate that coiling of a sigmoid sinus diverticulum can treat pulsatile tinnitus. We hypothesized that MR imaging 4D flow and computational fluid dynamics would reveal distinct blood flow patterns in the venous outflow tract in these patients. MATERIALS AND

methodsPatients with pulsatile tinnitus of suspected venous etiology underwent MR imaging at 3T, using venous phase contrast-enhanced MR angiography, 4D flow, and 2D phase contrast. The contrast-enhanced MRA contours were evaluated to determine the presence and extent of a sigmoid sinus diverticulum. Computational fluid dynamics analysis was performed using the 4D flow inlet flow and the luminal contours from contrast-enhanced MRA as boundary conditions. In addition, computational fluid dynamics was performed for the expected post treatment conditions by smoothing the venous geometry to exclude the sigmoid sinus diverticulum from the anatomic boundary conditions. Streamlines were generated from the 4D flow and computational fluid dynamics velocity maps, and flow patterns were examined for the presence of rotational components.

resultsTwenty-five patients with pulsatile tinnitus of suspected venous etiology and 10 control subjects were enrolled. Five (20%) of the symptomatic subjects had sigmoid sinus diverticula, all associated with an upstream stenosis. In each of these patients, but none of the controls, a stenosis-related flow jet was directed toward the opening of the sigmoid sinus diverticulum with rotational flow patterns in the sigmoid sinus diverticulum and parent sigmoid sinus on both 4D flow and computational fluid dynamics.

conclusionsConsistent patterns of blood flow can be visualized in a sigmoid sinus diverticulum and the parent sinus using 4D flow and computational fluid dynamics. Strong components of rotational blood flow were seen in subjects with sigmoid sinus diverticula that were absent in controls.

Indexed as

AdultAgedCerebrovascular CirculationCranial SinusesDiverticulumFemaleHemodynamicsHumansHydrodynamicsMagnetic Resonance ImagingMaleMiddle AgedTinnitus

Identifiers

PMID30309843
PMCPMC6239885
OpenAlexW2897206894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.