ArticlePsychological medicine2019
Genetic risk for schizophrenia is associated with substance use in emerging adulthood: an event-level polygenic prediction model.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Trial
- Incidence and predictors of problem gambling in first-episode psychosis: A prospective multicentre cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Observational
- Psychotomimetic compensation versus sensitization.Pharmacology research & perspectives · 2024Review
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
- Addictive and other mental disorders: a call for a standardized definition of dual disorders.Translational psychiatry · 2022Review
- Coupled mixed model for joint genetic analysis of complex disorders with two independently collected data sets.BMC bioinformatics · 2021Article
- Partial Agonists and Dual Disorders: Focus on Dual Schizophrenia.Frontiers in psychiatry · 2021Article
- Polygenic Scores in Developmental Psychology: Invite Genetics In, Leave Biodeterminism Behind.Annual review of developmental psychology · 2020Article
- Using genetics for social science.Nature human behaviour · 2020Review
- Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
backgroundEmerging adulthood is a peak period of risk for alcohol and illicit drug use. Recent advances in psychiatric genetics suggest that the co-occurrence of substance use and psychopathology arises, in part, from a shared genetic etiology. We sought to extend this research by investigating the influence of genetic risk for schizophrenia on trajectories of four substance use behaviors as they occurred across emerging adulthood.
methodYoung adult participants of non-Hispanic European descent provided DNA samples and completed daily reports of substance use for 1 month per year across 4 years (N = 30 085 observations of N = 342 participants). A schizophrenia polygenic score was included in two-level hierarchical linear models designed to test associations between genetic risk for schizophrenia, participant age, and four substance use phenotypes.
resultsParticipants with a greater schizophrenia polygenic score experienced greater age-related increases in the likelihood of using substances across emerging adulthood (p < 0.005). Additionally, our results suggest that the polygenic score was positively associated with participants' overall likelihood to engage in illicit drug use but not alcohol-related substance use.
conclusionsThis study used a novel combination of polygenic prediction and intensive longitudinal methods to characterize the influence of genetic risk for schizophrenia on patterns of age-related change in substance use across emerging adulthood. Results suggest that genetic risk for schizophrenia has developmentally specific effects on substance use behaviors in a non-clinical population of young adults.
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