ArticleBMC medical genomics2018
Privacy-preserving logistic regression training.
Article in BMC medical genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multiple Strategies Confirm the Anti Hepatocellular Carcinoma Effect of Cinnamic Acid Based on the PI3k-AKT Pathway.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Classification of Maxillofacial Morphology by Artificial Intelligence Using Cephalometric Analysis Measurements.Diagnostics (Basel, Switzerland) · 2023Article
- The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Privacy-preserving federated neural network learning for disease-associated cell classification.Patterns (New York, N.Y.) · 2022Article
- Secure tumor classification by shallow neural network using homomorphic encryption.BMC genomics · 2022Article
- Machine learning analysis of gene expression profile reveals a novel diagnostic signature for osteoporosis.Journal of orthopaedic surgery and research · 2021Article
- Females and Males Show Differences in Early-Stage Transcriptomic Biomarkers of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2021Article
- High performance logistic regression for privacy-preserving genome analysis.BMC medical genomics · 2021Article
- A Potential Three-Gene-Based Diagnostic Signature for Hypertension in Pregnancy.International journal of general medicine · 2021Article
- Web-Based Privacy-Preserving Multicenter Medical Data Analysis Tools Via Threshold Homomorphic Encryption: Design and Development Study.Journal of medical Internet research · 2020Article
- Privacy-preserving semi-parallel logistic regression training with fully homomorphic encryption.BMC medical genomics · 2020Article
- Privacy-preserving approximate GWAS computation based on homomorphic encryption.BMC medical genomics · 2020Article
- iDASH secure genome analysis competition 2017.BMC medical genomics · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundLogistic regression is a popular technique used in machine learning to construct classification models. Since the construction of such models is based on computing with large datasets, it is an appealing idea to outsource this computation to a cloud service. The privacy-sensitive nature of the input data requires appropriate privacy preserving measures before outsourcing it. Homomorphic encryption enables one to compute on encrypted data directly, without decryption and can be used to mitigate the privacy concerns raised by using a cloud service.
methodsIn this paper, we propose an algorithm (and its implementation) to train a logistic regression model on a homomorphically encrypted dataset. The core of our algorithm consists of a new iterative method that can be seen as a simplified form of the fixed Hessian method, but with a much lower multiplicative complexity.
resultsWe test the new method on two interesting real life applications: the first application is in medicine and constructs a model to predict the probability for a patient to have cancer, given genomic data as input; the second application is in finance and the model predicts the probability of a credit card transaction to be fraudulent. The method produces accurate results for both applications, comparable to running standard algorithms on plaintext data.
conclusionsThis article introduces a new simple iterative algorithm to train a logistic regression model that is tailored to be applied on a homomorphically encrypted dataset. This algorithm can be used as a privacy-preserving technique to build a binary classification model and can be applied in a wide range of problems that can be modelled with logistic regression. Our implementation results show that our method can handle the large datasets used in logistic regression training.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.