ArticleAnnals of the American Thoracic Society2019
Risks of Benzodiazepines in Chronic Obstructive Pulmonary Disease with Comorbid Posttraumatic Stress Disorder.
Article in Annals of the American Thoracic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prescribed benzodiazepines and suicidal behaviors: a systematic review, meta-analysis, and clinical implications.BMC psychiatry · 2026Pooled it
- Short-term sleep benefitsFrontiers in pharmacology · 2026Pooled it
- Data linkage studies on veteran suicidality: a scoping review of the field, knowledge gaps and evidence appraisal.BMC psychiatry · 2026Article
- Do Antidepressants Worsen COPD Outcomes in Depressed Patients with COPD?Pulmonary therapy · 2024Review
- Article
- Association Between Hypnotic Use and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease and Insomnia.International journal of chronic obstructive pulmonary disease · 2023Article
- Update in Chronic Obstructive Pulmonary Disease 2019.American journal of respiratory and critical care medicine · 2020Review
- Respiratory events associated with concomitant opioid and sedative use among Medicare beneficiaries with chronic obstructive pulmonary disease.BMJ open respiratory research · 2020Article
- Pathogenesis of obstructive sleep apnea in individuals with the COPD + OSA Overlap syndrome versus OSA alone.Physiological reports · 2020Article
- Association between benzodiazepines and suicide risk: a matched case-control study.BMC psychiatry · 2019Article
- Association of Opioid and Benzodiazepine Use with Adverse Respiratory Events in Older Adults with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2019Article
- Center Predictors of Long-Term Benzodiazepine Use in Chronic Obstructive Pulmonary Disease and Post-traumatic Stress Disorder.Annals of the American Thoracic Society · 2019Article
- Benzodiazepines Safe in Chronic Obstructive Pulmonary Disease? Don't Hold Your Breath.Annals of the American Thoracic Society · 2019Article
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8 authors.
Funding
Abstract
rationaleBenzodiazepines are associated with mortality and poor outcomes among patients with chronic obstructive pulmonary disease (COPD), but use of benzodiazepines for dyspnea among patients with end-stage disease may confound this relationship.
objectivesAssess the mortality risks of long-term benzodiazepine exposure among patients with COPD and comorbid post-traumatic stress disorder (PTSD), patients with chronic nonrespiratory indications for benzodiazepines.
methodsWe identified all patients with COPD and PTSD within the Veteran's Health Administration between 2010 and 2012. We calculated propensity scores for benzodiazepine use and compared overall and cause-specific mortality of patients with long-term (≥90 d) benzodiazepine use relative to matched patients without use. Secondary analyses assessed propensity-adjusted survival by characteristics of benzodiazepine exposure.
resultsAmong 44,555 eligible patients with COPD and PTSD, 23.6% received benzodiazepines long term. In the matched sample of 19,552 patients, we observed no mortality difference (hazard ratio [HR] for long-term use, 1.06; 95% confidence interval [CI], 0.95-1.18) but greater risk of death by suicide among those with long-term use (HR, 2.33; 95% CI, 1.14-4.79). Among matched and unmatched patients, short-term benzodiazepine use, but not long-term use, was associated with increased mortality (short-term: HR, 1.16; 95% CI, 1.05-1.28; long-term: HR, 1.03; 95% CI, 0.94-1.13).
conclusionsRisks for respiratory compromise related to long-term benzodiazepine use in COPD may be less than previously estimated, but short-term use of benzodiazepines could still pose a mortality risk. Suicide associated with benzodiazepine use in this population warrants further investigation.
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