Evidence map›Paper›PMID 30309231›Full record

ArticleJournal of stroke2018

Outcome Prediction Using Perfusion Parameters and Collateral Scores of Multi-Phase and Single-Phase CT Angiography in Acute Stroke: Need for One, Two, Three, or Thirty Scans?

Katharina Schregel, Ioannis Tsogkas, Carolin Peter, Antonia Zapf, Daniel Behme, Marlena Schnieder, Ilko L Maier, Jan Liman, Michael Knauth, Marios-Nikos Psychogios

Open access · diamondAbstract read
In one paragraph

Article in Journal of stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Contralateral hemispheric cerebral blood flow can predict short-term clinical outcomes in patients with recent small subcortical infarcts.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Optimization of collateral grading on computer tomography angiography.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Observational
  15. Multimodal CT in Acute Stroke.Current neurology and neuroscience reports · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katharina SchregelInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
Ioannis TsogkasInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
Carolin PeterInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
Antonia ZapfDepartment of Medical Statistics, University Medical Center Goettingen, Goettingen, Germany.
Daniel BehmeInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
Marlena SchniederDepartment of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Ilko L MaierDepartment of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Jan LimanDepartment of Neurology, University Medical Center Goettingen, Goettingen, Germany.
Michael KnauthInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
Marios-Nikos PsychogiosInstitute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.
University of Göttingen · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCollateral status is an important factor determining outcome in acute ischemic stroke (AIS). Hence, different collateral scoring systems have been introduced. We applied different scoring systems on single- and multi-phase computed tomography (CT) angiography (spCTA and mpCTA) and compared them to CT perfusion (CTP) parameters to identify the best method for collateral evaluation in patients with AIS.

methodsA total of 102 patients with AIS due to large vessel occlusion in the anterior circulation who underwent multimodal CT imaging and who were treated endovascularly were included. Collateral status was assessed on spCTA and mpCTA using four different scoring systems and compared to CTP parameters. Logistic regression was performed for predicting favorable outcome.

resultsAll collateral scores correlated well with each other and with CTP parameters. Comparison of collateral scores stratified by extent of perfusion deficit showed relevant differences between groups (P<0.01 for each). An spCTA collateral score discriminated best between favorable and unfavorable outcome as determined using the modified Rankin Scale 3 months after stroke.

conclusions Collateral status evaluated on spCTA may suffice for outcome prediction and decision making in AIS patients, potentially obviating further imaging modalities like mpCTA or CTP.

Indexed as

Acute strokeCollateral circulationComputed tomography angiographyPerfusionTreatment outcome

Identifiers

PMID30309231
PMCPMC6186923
OpenAlexW2894839974

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.