Evidence map›Paper›PMID 30308948›Full record

ArticleMarine drugs2018

Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery.

Danielle H Demers, Matthew A Knestrick, Renee Fleeman, Rahmy Tawfik, Ala Azhari, Ashley Souza, Brian Vesely, Mandy Netherton, Rashmi Gupta, Beatrice L Colon and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Differential Growth Rates andMicrobiology spectrum · 2022
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Chromatographic editing enhances natural product discovery.Journal of pharmaceutical and biomedical analysis · 2019
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Danielle H DemersDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. dhdemers@mail.usf.edu.
Matthew A KnestrickDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. m.a.knestrick@gmail.com.
Renee FleemanDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA. rfleeman@utexas.edu.
Rahmy TawfikDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA. rtawfik@mail.usf.edu.
Ala AzhariDepartment of Global Health, University of South Florida, Tampa, FL 33613, USA. aazhari@kau.edu.sa.
Ashley SouzaDepartment of Global Health, University of South Florida, Tampa, FL 33613, USA. asouza@taskforce.org.
Brian VeselyDepartment of Global Health, University of South Florida, Tampa, FL 33613, USA. bvesely@health.usf.edu.
Mandy NethertonDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. Mandy.Netherton@ucf.edu.
Rashmi GuptaDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. Rashmi.Gupta@ucf.edu.
Beatrice L ColonDepartment of Molecular Medicine, University of South Florida, Tampa, FL 33613, USA. Beatrice.Colon@uga.edu.
Christopher A RiceDepartment of Global Health, University of South Florida, Tampa, FL 33613, USA. Christopher.Rice@uga.edu.ORCID 0000-0003-0672-9604
Mario A Rodríguez-PérezInstituto Politécnico Nacional, Centro de Biotecnología Genómica, Blvd. del Maestro esq. Elías Piña s/n. Reynosa 88710, Tamaulipas, Mexico. mrodriguez@ipn.mx.
Kyle H RohdeDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USA. Kyle.Rohde@ucf.edu.
Dennis E KyleDepartment of Global Health, University of South Florida, Tampa, FL 33613, USA. DENNIS.KYLE@uga.edu.
Lindsey N ShawDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA. shaw@usf.edu.
Bill J BakerDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA. bjbaker@usf.edu.ORCID 0000-0003-3033-5779

Funding

Lead Optimization of Bis-benzimidazole Analogs for Pathogenic Free-living AmoebaeR21AI119787 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI KYLE, DENNIS E · 2015 to 2016
$425k
Natural Product Treatments for LeishmaniasisR21AI103673 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI BAKER, BILL J, KYLE, DENNIS E · 2013 to 2014
$400k
Bioprospecting antibiotics in the fungal secondary metabolomeR21AI103715 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI BAKER, BILL J, SHAW, LINDSEY NEIL · 2013 to 2014
$391k
NIAID NIH HHS R21 AI103673NIAID NIH HHS R21 AI103715NIAID NIH HHS R21 AI119787NIH HHS AI103673NIH HHS AI103715
6 · The paper itself

Abstract

There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived endophytic fungi as a source of new antibiotics. Fungi cultured in the presence and absence of small molecule epigenetic modulators were screened against

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaCell LineCommunicable DiseasesDrug DiscoveryEndophytesFungiHistone Deacetylase InhibitorsMethyltransferasesMiceAnti-Bacterial AgentsHistone Deacetylase InhibitorsMethyltransferasesendophytic fungiepigenetic modificationinfectious disease drug discoverymangrovesscreening

Identifiers

PMID30308948
PMCPMC6212984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.