Evidence map›Paper›PMID 30308939›Full record

ArticleInternational journal of molecular sciences2018

Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target.

Chin-Sheng Hung, Sheng-Chao Wang, Yi-Ting Yen, Tzong-Huei Lee, Wu-Che Wen, Ruo-Kai Lin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 74 citations in OpenAlex.

  1. A Noninvasive Circulating Tumor DNA Methylation Classifier to Identify Benign Pulmonary Nodules.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
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  3. Review
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  8. Decoding the Epigenome of Breast Cancer.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Targeting one-carbon metabolism for cancer immunotherapy.Clinical and translational medicine · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Chin-Sheng HungDivision of Breast Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 110, Taiwan. hungcs@tmu.edu.tw.ORCID 0000-0002-9515-2036
Sheng-Chao WangPh.D Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. wsc0327@gmail.com.
Yi-Ting YenProfessional Master Program in Pharmaceutics and Biotechnology, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. chocayen0822@gmail.com.
Tzong-Huei LeeInstitute of Fisheries Science, National Taiwan University, Taipei 110, Taiwan. thlee1@ntu.edu.tw.
Wu-Che WenGolden Biotechnology Corporation, 15F., No. 27-6, Sec. 2, Zhongzheng E. Rd, Taipei, TW 110, Taiwan. wwc@goldenbiotech.com.tw.
Ruo-Kai LinPh.D Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. linruokai@tmu.edu.tw.ORCID 0000-0002-5153-0824
Taipei Medical University · TWGolden Biotech (Taiwan) · TWNational Taiwan University · TWTaipei Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung and breast cancer are the leading causes of mortality in women worldwide. The discovery of molecular alterations that underlie these two cancers and corresponding drugs has contributed to precision medicine. We found that CCND2 is a common target in lung and breast cancer. Hypermethylation of the

Indexed as

DNA MethylationAntineoplastic AgentsBiomarkers, TumorBreast NeoplasmsCell MovementCell ProliferationCyclin D2Dose-Response Relationship, DrugGene Expression Regulation, NeoplasticHumansLung NeoplasmsPrognosisPromoter Regions, GeneticProportional Hazards ModelsRNA, MessengerUbiquinoneAntineoplastic AgentsantroquinonolBiomarkers, TumorCCND2 protein, humanCyclin D2RNA, MessengerUbiquinoneAntrodia camphorataantroquinonol DCCND2circulating cell-free DNAhypermethylationlung adenocarcinomaprognostic factortriple-negative breast cancer (TNBC)tumor suppressor gene

Identifiers

PMID30308939
PMCPMC6213171
OpenAlexW2897016835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.