Evidence map›Paper›PMID 30308467›Full record

ReviewCurrent opinion in chemical biology2019

Understanding molecular mechanisms of disease through spatial proteomics.

Sandra Pankow, Salvador Martínez-Bartolomé, Casimir Bamberger, John R Yates

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. SFPQ Promotes Lung Cancer MalignancyFrontiers in oncology · 2022
    Article
  8. Article
  9. Article
  10. Subcellular proteomics.Nature reviews. Methods primers · 2021
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sandra PankowDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Salvador Martínez-BartoloméDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
Casimir BambergerDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States.
John R YatesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, United States. Electronic address: jyates@scripps.edu.
Scripps Research Institute · US

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Activity-dependent Development of Visual System DevelopmentR01EY011261 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 1996 to 2018
$11.1M
Proteogenetics of Autism Spectrum DisordersR01MH100175 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MUOTRI, ALYSSON R., YATES III, JOHN R · 2013 to 2025
$7.4M
Quantitative Proteome Analysis of Brain DevelopmentR01MH067880 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2003 to 2017
$7.1M
STRUCTURE AND FUNCTIONS OF THE NUCLEAR ENVELOPER01GM028521 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GERACE, LARRY R. · 1985 to 2020
$7.0M
Proteomic Profiling of CFTR Protein InteractionR01HL079442 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI BALCH, WILLIAM EDWARD, YATES III, JOHN R · 2005 to 2014
$4.6M
Molecular Discovery for Optic Nerve RegenerationU01EY027261 · NEI · STANFORD UNIVERSITY · PI GOLDBERG, JEFFREY L, HUBERMAN, ANDREW D · 2016 to 2019
$3.0M
Mapping the organization of the peripheral nuclear compartmentU01DA040709 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI GERACE, LARRY R. · 2015 to 2019
$2.9M
The CFTR InteractomeR01HL131697 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2016 to 2019
$1.9M
Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass SpectrometryR33CA212973 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2017 to 2019
$1.2M
Proteomic characterization of exosomes from AD patientsR56AG057459 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI RISSMAN, ROBERT, YATES III, JOHN R · 2017 to 2017
$844k
NCI NIH HHS R33 CA212973NEI NIH HHS R01 EY011261NEI NIH HHS U01 EY027261NHLBI NIH HHS R01 HL079442NHLBI NIH HHS R01 HL131697NIA NIH HHS R56 AG057459NIDA NIH HHS U01 DA040709NIGMS NIH HHS P41 GM103533NIGMS NIH HHS R01 GM028521NIMH NIH HHS R01 MH067880NIMH NIH HHS R01 MH100175
6 · The paper itself

Abstract

Mammalian cells are organized into different compartments that separate and facilitate physiological processes by providing specialized local environments and allowing different, otherwise incompatible biological processes to be carried out simultaneously. Proteins are targeted to these subcellular locations where they fulfill specialized, compartment-specific functions. Spatial proteomics aims to localize and quantify proteins within subcellular structures.

Indexed as

Protein Interaction MapsAnimalsCellular StructuresHumansProtein Interaction MappingProteinsProteomicsProteins

Identifiers

PMID30308467
PMCPMC6435883
OpenAlexW2897906189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.