ArticleNeuroImage. Clinical2018
Prenatal to postnatal trajectory of brain growth in complex congenital heart disease.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Brain volumes in congenital heart disease from childhood to adulthood: A pooled neuroimaging study.Neuroimage. Reports · 2026Article
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Cortical morphology and cognitive impairments in adolescents with complex congenital heart disease.Brain communications · 2026Article
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Research square · 2025Article
- The "Heart-and-Brain Interaction" in Newborns with Complex Congenital Heart Disease.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.Journal of perinatal medicine · 2025Article
- Alteration in Cortical Structure Mediating the Impact of Blood Oxygen-Carrying Capacity on Gross Motor Skills in Infants With Complex Congenital Heart Disease.Human brain mapping · 2025Article
- Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery-is there an association?Frontiers in cardiovascular medicine · 2025Article
- Children with Congenital Heart Diseases Exhibit Altered Deep Gray Matter Structures.Clinical neuroradiology · 2024Article
- Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024Review
- The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.Human brain mapping · 2024Article
- Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure.NeuroImage · 2024Article
- Fetal circulatory physiology and brain development in complex congenital heart disease: A multi-modal imaging study.Prenatal diagnosis · 2024Article
- Postnatal Brain Trajectories and Maternal Intelligence Predict Childhood Outcomes in Complex CHD.Journal of clinical medicine · 2024Article
- Fetal neuroimaging applications for diagnosis and counseling of brain anomalies: Current practice and future diagnostic strategies.Seminars in fetal & neonatal medicine · 2024Review
- Impact of postoperative necrotizing enterocolitis after neonatal cardiac surgery on neurodevelopmental outcome at 1 year of age.Frontiers in pediatrics · 2024Article
- Altered In Utero Metabolic Brain Trajectories in CHD: Going Beyond Fetal Brain Structure and Physiology.Journal of the American College of Cardiology · 2023Article
- Magnetic Resonance Spectroscopy of Brain Metabolism in Fetuses With Congenital Heart Disease.Journal of the American College of Cardiology · 2023Observational
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Altered brain development is a common feature of the neurological sequelae of complex congenital heart disease (CHD). These alterations include abnormalities in brain size and growth that begin prenatally and persist postnatally. However, the longitudinal trajectory of changes in brain volume from the prenatal to postnatal environment have not been investigated. We aimed to evaluate the trajectory of brain growth in a cohort of patients with complex CHD (n = 16) and healthy controls (n = 15) to test the hypothesis that patients with complex CHD would have smaller total brain volume (TBV) prenatally, which would become increasingly prominent by three months of age. Participants underwent fetal magnetic resonance imaging (MRI) at a mean of 32 weeks gestation, a preoperative/neonatal MRI shortly after birth, a postoperative MRI (CHD only), and a 3-month MRI to evaluate the trajectory of brain growth. Three-dimensional volumetric analysis was applied to the MRI data to measure TBV, as well as tissue-specific volumes of the cortical gray matter (CGM), white matter (WM), subcortical (deep nuclear) gray matter (SCGM), cerebellum, and cerebrospinal fluid (CSF). A random coefficients model was used to investigate longitudinal changes in TBV and demonstrated an altered trajectory of brain growth in the CHD population. The estimated slope for TBV from fetal to 3-month MRI was 11.5 cm
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