Trial reportAmerican journal of ophthalmology2018
Factors Associated With Graft Rejection in the Cornea Preservation Time Study.
Trial report in American journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Trial
- Donor Diabetes and 1-Year Descemet Membrane Endothelial Keratoplasty Success Rate: A Randomized Clinical Trial.JAMA ophthalmology · 2025Trial
- Impact of donor-recipient gender mismatch on outcomes in Descemet membrane endothelial keratoplasty (DMEK).Cell and tissue banking · 2026Article
- Evaluation and comparison of long-term outcomes of keratoplasty in adult and geriatric patient groups.BMC ophthalmology · 2026Article
- Machine learning methods to identify risk factors for corneal graft rejection in keratoconus.Scientific reports · 2024Article
- Clinical characteristics, risk factor analysis and outcomes in 61 eyes with graft rejection after descemet stripping endothelial keratoplasty, with a review of literature.International ophthalmology · 2024Review
- Article
- Fuchs endothelial corneal dystrophy: an updated review.International ophthalmology · 2024Review
- The impact of donor diabetes on corneal transplant immunity.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- A lack of an association between COVID-19 vaccination and corneal graft rejection: results of a large multi-country population based study.Eye (London, England) · 2023Article
- Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection.Translational vision science & technology · 2023Article
- Endothelial failure and rejection in recipients of corneas from the same donor.BMJ open ophthalmology · 2022Article
- Donor and Recipient Sex Matching and Corneal Graft Failure in High-Risk and Non-High-Risk Patients.Journal of ophthalmology · 2022Article
- Impact of gender mismatch on corneal graft rejection and rejection-related graft failure in repeat penetrating keratoplasty.PloS one · 2022Article
- Evaluation of Donor and Recipient Characteristics Involved in Descemet Stripping Automated Endothelial Keratoplasty Outcomes.Frontiers in medicine · 2021Article
- An endothelial rejection line following Descemet stripping automated endothelial keratoplasty.BMC ophthalmology · 2020Article
- Quantitative and qualitative evaluation of deep learning automatic segmentations of corneal endothelial cell images of reduced image quality obtained following cornea transplant.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Machine learning for segmenting cells in corneal endothelium images.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 1 country.
Funding
Abstract
purposeTo identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS).
designCohort study within a multicenter randomized clinical trial.
methodsA total of 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (n = 675) or 8-14 days (n = 655) and followed for 3 years. Central endothelial cell density (ECD) was determined by a central image analysis reading center. Multivariable Cox models adjusted for PT, recipient diagnosis, and surgeon effect were used to identify factors associated with rejection.
resultsCumulative probability of definite graft rejection was 3.6% (99% confidence interval 2.5%-5.3%). Younger recipient age was associated with graft rejection (P < .001; hazard ratio: 0.53 [0.33, 0.83] per decade). PT, donor-recipient sex mismatch, recipient diagnosis, recipient race, graft size, discontinuation of topical corticosteroids and immune-modulators, prior immunizations within 3 months, and prior glaucoma surgery were not associated with rejection (P > .01). Among clear grafts with an ECD measurement at baseline and 3 years (n = 913), endothelial cell loss (ECL) was greater in eyes that experienced a rejection episode (n = 27) than in those that did not (n = 886) (48% vs 38%, P = .03). Twelve of 44 eyes (27%) with definite graft rejection subsequently failed, comprising 15% of the 79 failures in the CPTS.
conclusionsGraft rejection is uncommon after DSAEK and more likely with younger age, in a study cohort mostly > 50 years old. Rejection increases ECL, but it is not a leading cause of DSAEK failure.
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