ArticleNeuron2018
Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.eLife · 2024Article
- Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.Nature communications · 2022Article
- Mafa-dependent GABAergic activity promotes mouse neonatal apneas.Nature communications · 2022Article
- A model for self-organization of sensorimotor function: the spinal monosynaptic loop.Journal of neurophysiology · 2022Article
- A transgenic mouse embryonic stem cell line for puromycin selection of V0Stem cell research & therapy · 2022Article
- Diseased, differentiated and difficult: Strategies for improved engineering ofFrontiers in cellular neuroscience · 2022Review
- A shared transcriptional code orchestrates temporal patterning of the central nervous system.PLoS biology · 2021Article
- Induction of Ventral Spinal V0 Interneurons from Mouse Embryonic Stem Cells.Stem cells and development · 2021Article
- The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord.International journal of molecular sciences · 2021Review
- Standardized Reporter Systems for Purification and Imaging of Human Pluripotent Stem Cell-derived Motor Neurons and Other Cholinergic Cells.Neuroscience · 2020Article
- Transplanting neural progenitor cells to restore connectivity after spinal cord injury.Nature reviews. Neuroscience · 2020Review
- V2a interneuron differentiation from mouse and human pluripotent stem cells.Nature protocols · 2019Article
- Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.Development (Cambridge, England) · 2019Article
- A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neuronal diversification is a fundamental step in the construction of functional neural circuits, but how neurons generated from single progenitor domains acquire diverse subtype identities remains poorly understood. Here we developed an embryonic stem cell (ESC)-based system to model subtype diversification of V1 interneurons, a class of spinal neurons comprising four clades collectively containing dozens of molecularly distinct neuronal subtypes. We demonstrate that V1 subtype diversity can be modified by extrinsic signals. Inhibition of Notch and activation of retinoid signaling results in a switch to MafA clade identity and enriches differentiation of Renshaw cells, a specialized MafA subtype that mediates recurrent inhibition of spinal motor neurons. We show that Renshaw cells are intrinsically programmed to migrate to species-specific laminae upon transplantation and to form subtype-specific synapses with motor neurons. Our results demonstrate that stem cell-derived neuronal subtypes can be used to investigate mechanisms underlying neuronal subtype specification and circuit assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.