Evidence map›Paper›PMID 30308148›Full record

ArticleCell host & microbe2018

A Sugar Rush for Innate Immunity.

Pontus Orning, Trude H Flo, Egil Lien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. HMGB1 as a danger signal in vascular remodeling.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pontus OrningCentre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway; Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA.
Trude H FloCentre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Egil LienCentre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway; Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA. Electronic address: egil.lien@umassmed.edu.

Funding

Bacterial inhibition of Pyrin inflammasome activationR21AI128547 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2017 to 2018
$461k
NIAID NIH HHS R21 AI128547
6 · The paper itself

Abstract

Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-κB activation and identified the bacterial sugar ADP-Hep as its ligand.

Indexed as

AnimalsCarrier ProteinsGram-Negative BacteriaHost-Pathogen InteractionsImmunity, InnateInflammationMiceMice, KnockoutNF-kappa BProtein KinasesReceptors, Pattern RecognitionSignal TransductionSugarsType III Secretion SystemsALPK1 protein, mouseCarrier ProteinsNF-kappa BProtein KinasesReceptors, Pattern RecognitionSugarsType III Secretion Systems

Identifiers

PMID30308148
PMCPMC6510543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.