Evidence map›Paper›PMID 30308088›Full record

ReviewBritish journal of clinical pharmacology2019

Update on pharmacologically-relevant vitamin D analogues.

Glenville Jones, Martin Kaufmann

Open access · bronzeAbstract readReview
In one paragraph

Review in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Structure and the Anticancer Activity of Vitamin D Receptor Agonists.International journal of molecular sciences · 2024
    Review
  6. Article
  7. The 1α,25(OH)Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  8. Update on pharmacologically-relevant vitamin D analogues.British journal of clinical pharmacology · 2019
    Review
  9. Drugs for the treatment of metabolic bone diseases.British journal of clinical pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Glenville JonesDepartment of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0001-7402-3473
Martin KaufmannDepartment of Biomedical & Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Queen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacologists have been interested in vitamin D since its metabolism was elucidated in the early 1970s. Despite the synthesis of thousands of vitamin D analogues in the hope of separating its calcemic and anti-proliferative properties, few molecules have reached the market for use in the treatment of clinical conditions from psoriasis to chronic kidney disease. This review discusses vitamin D drugs, recently developed or still under development, for use in various diseases, but in particular bone disease. In the process we explore the mechanisms postulated to explain the action of these vitamin D analogues including action through the vitamin D receptor, action through other receptors e.g. FAM57B2 and dual action on transcriptional processes.

Indexed as

24,25-Dihydroxyvitamin D 3AnimalsBone Density Conservation AgentsBone Diseases, MetabolicBone RemodelingCalcifediolCalcitriolHumansReceptors, CalcitriolSignal TransductionTreatment OutcomeVitamins24,25-Dihydroxyvitamin D 3Bone Density Conservation AgentsCalcifediolCalcitriolReceptors, CalcitriolVDR protein, humanVitaminsbioequivalencecytochrome P450drug developmentgenetics and pharmacogeneticspharmacokineticstherapeutic drug monitoring

Identifiers

PMID30308088
PMCPMC6533488
OpenAlexW2902157948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.