Evidence map›Paper›PMID 30307778›Full record

ArticleJournal of adolescent and young adult oncology2019

Oral Medication Adherence Among Adolescents and Young Adults with Cancer Before and Following Use of a Smartphone-Based Medication Reminder App.

Lauri A Linder, Yelena P Wu, Catherine Fiona Macpherson, Brynn Fowler, Andrew Wilson, Yeonjung Jo, Se-Hee Jung, Bridget Parsons, Rebecca Johnson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of adolescent and young adult oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of mHealth apps on adherence and symptoms to oral anticancer medications: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  18. Day-to-Day Decision Making by Adolescents and Young Adults with Cancer.Journal of pediatric hematology/oncology nursing
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Lauri A Linder1 College of Nursing, University of Utah , Salt Lake City, Utah.
Yelena P Wu3 Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah , Salt Lake City, Utah.
Catherine Fiona Macpherson5 Seattle Children's Hospital , Seattle, Washington.
Brynn Fowler6 Comer Children's Hospital, University of Chicago , Chicago, Illinois.
Andrew Wilson1 College of Nursing, University of Utah , Salt Lake City, Utah.
Yeonjung Jo1 College of Nursing, University of Utah , Salt Lake City, Utah.
Se-Hee Jung1 College of Nursing, University of Utah , Salt Lake City, Utah.
Bridget Parsons3 Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah , Salt Lake City, Utah.
Rebecca Johnson9 Multicare Health System, Mary Bridge Children's Hospital , Tacoma, Washington.
University of Utah · USMultiCare Health System · USPAREXEL International (United Kingdom) · GBPrimary Children's Hospital · USSeattle Children's Hospital · USUniversity of Chicago · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
NCATS NIH HHS UL1 TR002538
6 · The paper itself

Abstract

purposeThis study evaluated oral medication adherence among adolescents and young adults (AYAs) with cancer during a trial of a smartphone-based medication reminder application (app).

methodsTwenty-three AYAs receiving at least one prescribed, scheduled oral medication related to their outpatient cancer treatment participated in this 12-week single-group interrupted time series longitudinal design study. Baseline oral medication adherence was monitored using electronic monitoring caps for 4 weeks. Participants then used a medication reminder app and continued to have their oral medication adherence monitored for 8 weeks. Participants completed an electronically administered weekly survey addressing perceived adherence and reasons for nonadherence.

resultsFour adherence phenotypes were identified using visual graphical analysis of individual participants' weekly adherence: (1) high adherence during the preintervention and intervention periods (n = 13), (2) low preintervention adherence and improved adherence during the intervention period (n = 3), (3) low adherence during both periods (n = 6), and (4) high preintervention adherence and low adherence during the intervention period (n = 1). Growth curve models did not show significant changes in adherence by preintervention versus intervention trajectories (p > 0.05); however, the variance in adherence during the intervention narrowed for more highly adherent AYAs. "Forgetfulness" was the most frequently reported reason for nonadherence.

conclusionAlthough overall adherence did not improve following use of the app, the variance decreased for more highly adherent participants. Additional or alternative interventions are needed for AYAs with persistently poor adherence. Assessment of adherence patterns may support individualized recommendation of tailored interventions.

Indexed as

Drug MonitoringAccess to InformationAdministration, OralAdolescentAdultAntineoplastic AgentsFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleNeoplasmsPrognosisReminder SystemsSmartphoneSurveys and QuestionnairesAntineoplastic Agentsadherenceinterventionmobile technologyoral medicationstechnology

Identifiers

PMID30307778
PMCPMC6479252
OpenAlexW2895989054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.