ArticleJournal of veterinary internal medicine2018
The pharmacokinetics of gabapentin in cats.
Article in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Pharmacokinetics of Single Dose and Multidose Oral Gabapentin in Goats (Capra aegagrus hircus).Journal of veterinary pharmacology and therapeutics · 2025Article
- Clinical therapeutics in feline medicine: updates for old and new drugs.Journal of feline medicine and surgery · 2025Review
- A Systematic Review of the Sedative, Behavioral, Analgesic and Cardiovascular Effects of Gabapentin in Cats.Veterinary sciences · 2025Review
- Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Veterinary sciences · 2025Article
- Development and Validation of an LC-MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats.Animals : an open access journal from MDPI · 2025Article
- A comparative study between integrative practices and preappointement gabapentin on serum cortisol in cats.Veterinary research communications · 2024Article
- Evaluation of the sedative properties of oral trazodone, gabapentin or their combination in healthy cats.Journal of feline medicine and surgery · 2024Article
- Use of Gabapentin or Alprazolam in Cats during Postoperative, Short-Term Hospitalization.Animals : an open access journal from MDPI · 2024Article
- Effect of gabapentin on ambulatory, direct, systemic arterial blood pressure in apparently healthy cats in the at-home and in-clinic environments.Journal of feline medicine and surgery · 2023Article
- Gabapentin: Clinical Use and Pharmacokinetics in Dogs, Cats, and Horses.Animals : an open access journal from MDPI · 2023Review
- Does preappointment gabapentin affect neurological examination findings? A prospective, randomized and blinded study in healthy cats.Journal of feline medicine and surgery · 2023Article
- Pregabalin Alleviates Anxiety and Fear in Cats during Transportation and Veterinary Visits-A Clinical Field Study.Animals : an open access journal from MDPI · 2023Article
- Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats.Frontiers in veterinary science · 2023Article
- Serum concentrations of gabapentin in cats with chronic kidney disease.Journal of feline medicine and surgery · 2022Article
- Behavioral and cardiovascular effects of a single dose of gabapentin or melatonin in cats: a randomized, double-blind, placebo-controlled trial.Journal of feline medicine and surgery · 2022Article
- Evaluation of the effects of gabapentin on the physiologic and echocardiographic variables of healthy cats: a prospective, randomized and blinded study.Journal of feline medicine and surgery · 2022Article
- Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats.Journal of veterinary pharmacology and therapeutics · 2022Article
- 2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats.Journal of feline medicine and surgery · 2022Article
- Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development.Molecules (Basel, Switzerland) · 2021Article
- A pilot study of transdermal gabapentin in cats.Journal of veterinary internal medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats. Despite this common and chronic usage, clinically relevant pharmacokinetic data is lacking.
objectivesTo evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats. ANIMALS: Eight research-purpose mixed-breed cats.
methodsCats were enrolled in a serial order, non-randomized pharmacokinetic study. Gabapentin was administered as an IV bolus (5 mg/kg), orally (10 mg/kg) as a single dose or twice daily for 2 weeks, or as a transdermal gel (10 mg/kg) in serial order. Serial blood samples were collected up to 48 hours. Plasma concentrations were determined using Ultra Performance Liquid Chromatography-Mass Spectrometry. Compartmental analysis was used to generate gabapentin time-concentration models.
resultsAfter IV administration CL (median (range)) and terminal half-life were 160.67 mL/kg*hr (119.63-199.11) and 3.78 hours (3.12-4.47), respectively. The oral terminal half-life was 3.63 hours (2.96-4.77), and 3.72 hours (3.12-4.51) for single and repeated dosing. T IMPORTANCE: Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long-term treatment. As prepared, the transdermal route is an inappropriate choice for drug administration. These relevant data are important for future studies evaluating potential efficacy of the medication for treating chronic pain states in cats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.