ArticleMedical physics2018
Development of an attenuation correction method for direct x-ray fluorescence (XRF) imaging utilizing gold L-shell XRF photons.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- CT-Based Attenuation Correction Algorithm for Quantitative L-Shell X-Ray Fluorescence Imaging of Gold Nanoparticles in Murine Tumor Tissues.Diseases (Basel, Switzerland) · 2025Article
- Monte Carlo Modeling of An Experimental Benchtop L-shell X-ray Fluorescence Imaging/CT System Adopting Two Silicone Drift Detectors.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2025Article
- X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study.Cancers · 2021Article
- High-sensitivity imaging and quantification of intratumoral distributions of gold nanoparticles using a benchtop x-ray fluorescence imaging system.Optics letters · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis work proposes a semiempirical correction method for attenuation of x-ray fluorescence (XRF) photons and/or an excitation beam during direct XRF imaging (i.e., mapping) of gold nanoparticle (GNP) distribution utilizing gold L-shell XRF photons.
methodsThe current method was first devised by finding the two following relationships: (a) ratio of gold XRF peak intensity (L
resultsThe results show that the ratio of gold L-shell XRF peak intensities allowed an estimation of the pathlength of XRF photons, thus can be utilized to correct for attenuation of XRF photons after emission. The results also demonstrate that N
conclusionsThe current results suggest that the developed attenuation correction method plays an essential role for the detection of GNPs on the order of parts-per-million, and also for the determination of GNP concentration/location within the imaging object made of tissue-like media, without any prior knowledge of the imaging object shape, under the conditions deemed relevant to biomedical applications of gold L-shell XRF-based imaging.
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