ArticleEuropean heart journal. Cardiovascular Imaging2019
Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging.
Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- The SGLT2 inhibitor empagliflozin reduces tissue sodium content in patients with chronic heart failure: results from a placebo-controlled randomised trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Trial
- Improved Myocardial Sodium Quantification at 7 T Using InterleavedMagnetic resonance in medicine · 2026Article
- Quantitative abdominal sodium MRI combined with 32-channel proton pTx MRI at 7 Tesla in a large field-of-view.Magnetic resonance in medicine · 2025Article
- InterleavedMagnetic resonance in medicine · 2025Article
- A new approach to characterize cardiac sodium storage by combining fluorescence photometry and magnetic resonance imaging in small animal research.Scientific reports · 2024Article
- Water and Electrolyte Content in Salt-Dependent HYpertension in the SKIn (WHYSKI): Effect of Surgical Cure of Primary Aldosteronism.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- 2D sodium MRI of the human calf using half-sinc excitation pulses and compressed sensing.Magnetic resonance in medicine · 2024Article
- Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension.Antioxidants (Basel, Switzerland) · 2023Article
- Recent Advances in Sodium Magnetic Resonance Imaging and Its Future Role in Kidney Disease.Journal of clinical medicine · 2023Review
- Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism.Frontiers in physiology · 2023Article
- Non-invasive assessment of tissue sodium content in patients with primary adrenal insufficiency.European journal of endocrinology · 2022Article
- NaThe Journal of physiology · 2022Article
- Does Excess Tissue Sodium Storage Regulate Blood Pressure?Current hypertension reports · 2022Review
- Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study.European journal of endocrinology · 2022Article
- The first observation of osmotically neutral sodium accumulation in the myocardial interstitium.Scientific reports · 2021Article
- Reduction of Tissue NaKidney international reports · 2021Article
- Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2021Review
- Tolvaptan treatment in an adult Fontan patient with protein-losing enteropathy: a serialTherapeutic advances in chronic disease · 2021Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSodium intake has been linked to left ventricular hypertrophy independently of blood pressure, but the underlying mechanisms remain unclear. Primary hyperaldosteronism (PHA), a condition characterized by tissue sodium overload due to aldosterone excess, causes accelerated left ventricular hypertrophy compared to blood pressure matched patients with essential hypertension. We therefore hypothesized that the myocardium constitutes a novel site capable of sodium storage explaining the missing link between sodium and left ventricular hypertrophy. METHODS AND
resultsUsing 23Na magnetic resonance imaging, we investigated relative sodium signal intensities (rSSI) in the heart, calf muscle, and skin in 8 PHA patients (6 male, median age 55 years) and 12 normotensive healthy controls (HC) (8 male, median age 61 years). PHA patients had a higher mean systolic 24 h ambulatory blood pressure [152 (140; 163) vs. 125 (122; 130) mmHg, P < 0.001] and higher left ventricular mass index [71.0 (63.5; 106.8) vs. 55.0 (50.3; 66.8) g/m2, P = 0.037] than HC. Compared to HC, PHA patients exhibited significantly higher rSSI in the myocardium [0.31 (0.26; 0.34) vs. 0.24 (0.20; 0.27); P = 0.007], calf muscle [0.19 (0.16; 0.22) vs. 0.14 (0.13; 0.15); P = 0.001] and skin [0.28 (0.25; 0.33) vs. 0.19 (0.17; 0.26); P = 0.014], reflecting a difference of +27%, +38%, and +39%, respectively. Treatment of PHA resulted in significant reductions of the rSSI in the myocardium, calf muscle and skin by -13%, -27%, and -29%, respectively.
conclusionMyocardial tissue rSSI is increased in PHA patients and treatment of aldosterone excess effectively reduces rSSI, thus establishing the myocardium as a novel site of sodium storage in addition to skeletal muscle and skin.
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