ArticleCerebral cortex (New York, N.Y. : 1991)2019
Heritability of Gray Matter Structural Covariation and Tool Use Skills in Chimpanzees (Pan troglodytes): A Source-Based Morphometry and Quantitative Genetic Analysis.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Evolution of the frontal aslant tract and implications for primate vocalization and human speech.Nature communications · 2026Article
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Article
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.Neurobiology of aging · 2023Article
- Simulation and social network analysis provide insight into the acquisition of tool behaviour in hybrid macaques.Proceedings. Biological sciences · 2023Article
- Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The parietal lobe evolution and the emergence of material culture in the human genus.Brain structure & function · 2023Review
- The evolution of hierarchical structure building capacity for language and music: a bottom-up perspective.Primates; journal of primatology · 2022Review
- Article
- Neuroanatomical correlates of individual differences in the object choice task in chimpanzees (Frontiers in psychology · 2022Article
- Age- and cognition-related differences in the gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis.American journal of primatology · 2021Article
- Causal structural covariance network revealing atrophy progression in Alzheimer's disease continuum.Human brain mapping · 2021Article
- Comparative morphology of the corpus callosum across the adult lifespan in chimpanzees (Pan troglodytes) and humans.The Journal of comparative neurology · 2021Article
- Reproducibility of leftward planum temporale asymmetries in two genetically isolated populations of chimpanzees (Proceedings. Biological sciences · 2020Article
- Greater variability in chimpanzee (Proceedings. Biological sciences · 2020Article
- AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees.Genes, brain, and behavior · 2020Article
- Development of a control task for clarifying the neural mechanisms underlying tool-use behavior in rats (MethodsX · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nonhuman primates, and great apes in particular, possess a variety of cognitive abilities thought to underlie human brain and cognitive evolution, most notably, the manufacture and use of tools. In a relatively large sample (N = 226) of captive chimpanzees (Pan troglodytes) for whom pedigrees are well known, the overarching aim of the current study was to investigate the source of heritable variation in brain structure underlying tool use skills. Specifically, using source-based morphometry (SBM), a multivariate analysis of naturally occurring patterns of covariation in gray matter across the brain, we investigated (1) the genetic contributions to variation in SBM components, (2) sex and age effects for each component, and (3) phenotypic and genetic associations between SBM components and tool use skill. Results revealed important sex- and age-related differences across largely heritable SBM components and associations between structural covariation and tool use skill. Further, shared genetic mechanisms appear to account for a heritable link between variation in both the capacity to use tools and variation in morphology of the superior limb of the superior temporal sulcus and adjacent parietal cortex. Findings represent the first evidence of heritability of structural covariation in gray matter among nonhuman primates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.