ArticleCerebral cortex (New York, N.Y. : 1991)2018
Functional Parcellation of the Cerebral Cortex Across the Human Adult Lifespan.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Individualized Mapping of Functional Brain Networks in Older Adulthood.bioRxiv : the preprint server for biology · 2026Article
- The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging.Scientific data · 2025Article
- Network segregation is associated with processing speed in the cognitively healthy oldest-old.eLife · 2025Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Deep learning-based embedding of functional connectivity profiles for precision functional mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Issues of parcellation in the calculation of structure-function coupling.Nature reviews. Neuroscience · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- Review
- Constructing fine-grained spatiotemporal neonatal functional atlases with spectral functional network learning.Human brain mapping · 2024Article
- Brain gray matter morphometry relates to onset age of bilingualism and theory of mind in young and older adults.Scientific reports · 2024Article
- Measures of resting-state brain network segregation and integration vary in relation to data quantity: implications for within and between subject comparisons of functional brain network organization.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Functional parcellation of the neonatal cortical surface.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Resting-state functional network segregation of the default mode network predicts valence bias across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain topology underlying executive functions across the lifespan: focus on the default mode network.Frontiers in psychology · 2024Article
- Article
- Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.Aging brain · 2024Article
- Dissociable Effects of Alzheimer's Disease-Related Cognitive Dysfunction and Aging on Functional Brain Network Segregation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Functional parcellation of the neonatal brain.bioRxiv : the preprint server for biology · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Adult aging is associated with differences in structure, function, and connectivity of brain areas. Age-based brain comparisons have typically rested on the assumption that brain areas exhibit a similar spatial organization across age; we evaluate this hypothesis directly. Area parcellation methods that identify locations where resting-state functional correlations (RSFC) exhibit abrupt transitions (boundary-mapping) are used to define cortical areas in cohorts of individuals sampled across a large range of the human adult lifespan (20-93 years). Most of the strongest areal boundaries are spatially consistent across age. Differences in parcellation boundaries are largely explained by differences in cortical thickness and anatomical alignment in older relative to younger adults. Despite the parcellation similarities, age-specific parcellations exhibit better internal validity relative to a young-adult parcellation applied to older adults' data, and age-specific parcels are better able to capture variability in task-evoked functional activity. Incorporating age-specific parcels as nodes in RSFC network analysis reveals that the spatial topography of the brain's large-scale system organization is comparable throughout aging, but confirms that the segregation of systems declines with increasing age. These observations demonstrate that many features of areal organization are consistent across adulthood, and reveal sources of age-related brain variation that contribute to the differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.