ArticleAge and ageing2019
Relation of cigarette smoking and alcohol drinking in midlife with risk of cognitive impairment in late life: the Singapore Chinese Health Study.
Article in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Association Between Brain Care Score and Cognitive Performance: Findings From a Community-Based Cohort in Singapore.Brain and behavior · 2026Article
- Obesity-induced cognitive impairment: Underlying mechanisms and therapeutic prospects.Metabolism open · 2026Review
- Prevalence and associated factors of cognitive impairment among hospitalized older adults with depression: a cross-sectional study from a tertiary psychiatric hospital in Guangzhou, China.Frontiers in public health · 2026Article
- Smoking is associated with increased risk for dementia: the HUNT study, Norway.BMC public health · 2025Article
- Development and validation of a prediction model for the depressive symptom risk in commercial airline pilots.The EPMA journal · 2025Article
- Association between sleep quality and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.BMC public health · 2025Article
- Closing the gap in dementia research by community-based cohort studies in the Chinese population.The Lancet regional health. Western Pacific · 2025Review
- Leisure activity engagement attenuates the risks of cognitive impairment induced by unhealthy plant-based diets: a nationwide cohort study.European journal of clinical nutrition · 2025Article
- Latent profiles and correlates factors of cognitive function in older adults: a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China.Frontiers in aging neuroscience · 2025Article
- An analysis of the mediating influence of depression on the association between early-life caregiver relationships and cognitive function: a cohort study based on the CHARLS database.Frontiers in psychiatry · 2025Article
- Late-life psychiatric factors and life satisfaction are associated with cognitive errors: evidence from an experimental module of a large-scale survey in India.Scientific reports · 2024Article
- Risk factors for the neurodegenerative dementias in the Western Pacific region.The Lancet regional health. Western Pacific · 2024Review
- The prevalence and risk factors study of cognitive impairment: Analysis of the elderly population of Han nationality in Hunan province, China.CNS neuroscience & therapeutics · 2024Article
- Former smoking, but not active smoking, is associated with delirium in postoperative ICU patients: a matched case-control study.Frontiers in psychiatry · 2024Article
- Determinants of semantic and episodic memory decline among older adults in Ghana: Evidence from the WHO study on global AGEing and adult health Ghana wave 2.Dialogues in health · 2023Article
- The Influence of Alcohol Consumption, Depressive Symptoms and Sleep Duration on Cognition: Results from the China Health and Retirement Longitudinal Study.International journal of environmental research and public health · 2022Article
- Lung function impairment in relation to cognition and vascular brain lesions: the Rotterdam Study.Journal of neurology · 2022Article
- Smoking Status and Cognitive Function in a National Sample of Older Adults.Frontiers in psychiatry · 2022Article
- Studying the relationship between cognitive impairment and frailty phenotype: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program.Journal of diabetes and metabolic disorders · 2021Article
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Authors and funding
7 authors.
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Abstract
Background: the relations of cigarette smoking and alcohol drinking with risk of cognitive impairment remain inconsistent. Methods: to examine the independent and joint relations of smoking and alcohol drinking with cognitive impairment, we used data from 16,948 men and women, who had been followed-up for 16-23 (mean of 20) years as participants of the Singapore Chinese Health Study, a population-based prospective cohort. Data on smoking and alcohol drinking were collected at baseline (1993-98), when participants were aged 45-74 (mean 53) years. Cognition was assessed using a 30-item Mini-Mental State Examination during follow-up three visits (2014-16), when participants were aged 61-96 (mean 73) years. Multivariable logistic regression models were used to estimate the odd ratios (ORs) and 95% confidence intervals (CIs). Results: cognitive impairment was present in 2,443 (14.4%) participants. Compared with non-current smokers, current smokers had 20% increased risk (OR = 1.20, 95% CI = 1.04-1.39). Compared with those who drank less than weekly, regular alcohol drinking (at least weekly) had 17% increased risk (OR = 1.17, 95% CI = 1.01-1.36). Compared with those who were neither smokers nor drinkers, those who were either current smokers or regular drinkers alone had no significantly increased risk, while the risk was highest in those who were both current smokers and regular drinkers (OR = 1.77, 95% CI = 1.39-2.26, Pinteraction = 0.003). Conclusions: co-existence of smoking and regular alcohol drinking at midlife had a much stronger impact than the individual factors on risk of cognitive impairment in late life.
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