ArticleCancer medicine2018
Role of serum EBV-VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Antibodies as biomarkers for cancer risk: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Antibodies Against Epstein-Barr Virus as Disease Markers of Gastric Cancer: A Systematic Review.Technology in cancer research & treatmentPooled it
- Causal association between EBV and gastritis, gastric cancer, and gastric ulcer: a two-sample Mendelian randomization study.Scientific reports · 2025Article
- Epstein-Barr Virus Infection Is Associated with Elevated Hepcidin Levels.International journal of molecular sciences · 2023Article
- Focusing onFrontiers in cellular and infection microbiology · 2023Review
- Epstein-Barr Virus is Associated with Gastric Cancer Precursor: Atrophic Gastritis.International journal of medical sciences · 2022Article
- Role of serum EBV-VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to investigate the role of serum EBV-VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV-VCA IgG serologic testing using enzyme-linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV-VCA IgG was significantly associated with GC and its precursor, conferring a 1.55- and 1.36-fold increased risk of GC and AG, respectively (P = 0.001, 95% CI = 1.21-1.99; P = 0.011, 95% CI = 1.07-1.72, respectively). The risk effects were more remarkable in younger, female, and Helicobacter pylori-negative individuals than in older, male, and H. pylori-positive individuals. EBV-VCA IgG-positive subjects had a lower PGI/II ratio than EBV-VCA IgG-negative subjects (median 8.0 vs 8.8, P = 0.001), especially those in the H. pylori-positive (median 6.1 vs 6.8, P = 0.027) and GC subgroups (median 6.4 vs 7.9, P = 0.020). In the intestinal GC subgroup, the survival of EBV-VCA IgG-positive patients was worse than that of EBV-VCA IgG-negative patients (P = 0.041, HR = 2.45, 95% CI = 1.04-5.78). Our study suggests that EBV-VCA IgG seropositivity has potential in predicting the risk of GC and its precursor as well as the prognosis of histologically classified GC.
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