SynthesisClinical oral implants research2018
The use of platelet-rich plasma to enhance the outcomes of implant therapy: A systematic review.
Synthesis in Clinical oral implants research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of platelet-rich plasma to enhance the outcomes of implant therapy: A systematic review.Clinical oral implants research · 2018Pooled it
- Biological and esthetic outcome of immediate dental implant with the adjunct pretreatment of immediate implants with platelet-rich plasma or photofunctionalization: A randomized controlled trial.Journal of Indian Prosthodontic SocietyTrial
- Angiogenic and Regenerative Potential of Plasma-Based and Plasma-Free Platelet Concentrates Obtained via Different Fractionation and Activation Methods.Bioengineering (Basel, Switzerland) · 2026Article
- 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: A Single-Round Survey on Sinus Lift and Alveolar Bone Augmentation Techniques.Clinical oral implants research · 2026Article
- PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025Review
- APCs in sinus floor augmentation.Periodontology 2000 · 2025Review
- How to explain the beneficial effects of platelet-rich plasma.Periodontology 2000 · 2025Review
- Effect of leukocyte and platelet-rich plasma on osseointegration after implant placement in mouse maxilla.Regenerative therapy · 2024Article
- Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses.Dentistry journal · 2024Review
- Assessment of the Effect of Phototherapy and PRP on the Immediate Implants: An Original Research.Journal of pharmacy & bioallied sciences · 2023Article
- Platelet-rich plasma alone is unable to trigger contact osteogenesis on titanium implant surfaces.International journal of implant dentistry · 2022Article
- Effects of Intraovarian Injection of Autologous Platelet-Rich Plasma on Ovarian Rejuvenation in Poor Responders and Women with Primary Ovarian Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- A retrospective preliminary histomorphometric and clinical investigation on sinus augmentation using enzyme-deantigenic, collagen-preserving equine bone granules and plasma rich in growth factors.International journal of implant dentistry · 2021Article
- Preclinical and Clinical Applications of Biomaterials in the Enhancement of Wound Healing in Oral Surgery: An Overview of the Available Reviews.Pharmaceutics · 2020Review
- The Number of Platelets in Patient's Blood Influences the Mechanical and Morphological Properties of PRP-Clot and Lysophosphatidic Acid Quantity in PRP.International journal of molecular sciences · 2019Article
- Article
- Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration.Frontiers in cardiovascular medicine · 2019Review
- Innovations in Dental Implants Integration: Optimizing dental implants performance utilizing stem cells and coatings.Biotechnology progressReview
- Use of platelet concentrates in oral surgery of patients with osteonecrosis: a scoping review.Brazilian dental journalArticle
- Effect of platelet concentrates on the treatment outcome of peri implantitis: A systematic review.Journal of Indian Society of PeriodontologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of platelet-rich plasma (PRP) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRP administration for bone regeneration and implant therapy?
methodsA literature search was conducted involving three databases: MEDLINE, EMBASE and Cochrane database followed by a hand search of relevant scientific journals. Human studies using PRP for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria, and quality assessments were conducted.
resultsIn total, out from the 9,497 titles meeting the original search criteria, 22 fulfilled the inclusion criteria and were chosen for data extraction. Among them were 15 randomized controlled trials (RCT) and seven controlled clinical trials (CCT). Overall, the risk of bias was moderate to high. A total of seven studies showed superior outcomes when PRP was added during sinus floor elevation and five showed no superior outcome. Three studies found a significant advantage of PRP for alveolar bone regeneration and another three studies for soft tissue healing. Three studies reported on beneficial effects of PRP directly during implant placement while another study failed to find significant differences. Due to the heterogeneity of study designs, no meta-analysis could be performed. SUMMARY AND
conclusionsDespite the lack of consistent evidence supporting the clinical benefit of PRP in healthy patients, PRP might have a positive effect on wound healing and bone regeneration in compromised patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.